High cholesterol level is essential for myelin membrane growth

Gesine Saher, Britta Brügger, Corinna Lappe-Siefke, +6

Nature Neuroscience

PhysiologyHigh Cholesterol LevelHyperlipidemiaMedicineAtherosclerosis +2

Targeted disruption of hormone-sensitive lipase results in male sterility and adipocyte hypertrophy, but not in obesity

Jun-ichi Osuga, Shun Ishibashi, Teruaki Oka, +8

Proceedings of the National Academy of Sciences

Absence of ACAT-1 Attenuates Atherosclerosis but Causes Dry Eye and Cutaneous Xanthomatosis in Mice with Congenital Hyperlipidemia

Hiroaki Yagyu, Tetsuya Kitamine, Jun-ichi Osuga, +17

Journal of Biological Chemistry

Embryonic Lethality and Defective Neural Tube Closure in Mice Lacking Squalene Synthase

Ryuichi Tozawa, Shun Ishibashi, Jun-ichi Osuga, +11

Journal of Biological Chemistry

Early Embryonic Lethality Caused by Targeted Disruption of the 3-Hydroxy-3-methylglutaryl-CoA Reductase Gene

Ken Ohashi, Jun-ichi Osuga, Ryuichi Tozawa, +13

Journal of Biological Chemistry

Novel mutations in the microsomal triglyceride transfer protein gene causing abetalipoproteinemia

Ken Ohashi, Shun Ishibashi, Jun-ichi Osuga, +10

Journal of Lipid Research

Asialoglycoprotein Receptor Deficiency in Mice Lacking the Major Receptor Subunit

Ryuichi Tozawa, Shun Ishibashi, Jun-ichi Osuga, +13

Journal of Biological Chemistry

Synthesis of Novel 4,1-Benzoxazepine Derivatives as Squalene Synthase Inhibitors and Their Inhibition of Cholesterol Synthesis

Takashi Miki, Masakuni Kori, Hiroshi Mabuchi, +5

Journal of Medicinal Chemistry

Comparing myotoxic effects of squalene synthase inhibitor, T-91485, and 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors in human myocytes

Tomoyuki Nishimoto, Ryuichi Tozawa, Yuichiro Amano, +3

Biochemical Pharmacology

Human MyocytesBiochemistryMedicineToxicologyPharmacotherapy +8

Lipid‐lowering properties of TAK‐475, a squalene synthase inhibitor, <i>in vivo</i> and <i>in vitro</i>

Tomoyuki Nishimoto, Yuichiro Amano, Ryuichi Tozawa, +4

British Journal of Pharmacology