Purification of cachectin, a lipoprotein lipase-suppressing hormone secreted by endotoxin-induced RAW 264.7 cells.

Bruce Beutler, James A. Mahoney, Nguyen Le Trang, +2

The Journal of Experimental Medicine

ImmunologyCellular PhysiologyInflammationEnzyme Lipoprotein LipaseCell Signaling +16

Transcriptional repression of the GLUT4 and C/EBP genes in 3T3-L1 adipocytes by tumor necrosis factor-alpha.

Jacqueline M. Stephens, P H Pekala

Journal of Biological Chemistry

Chronic Tnf TreatmentImmunologyC/ebp GenesTranscriptional RepressionInsulin Signaling +22

Sequence, tissue distribution, and differential expression of mRNA for a putative insulin-responsive glucose transporter in mouse 3T3-L1 adipocytes.

Klaus H. Kaestner, Robert J. Christy, John C. McLenithan, +4

Proceedings of the National Academy of Sciences

Metabolic RemodelingInsulin SignalingMouse 3T3-l1 AdipocytesMouse Skeletal MuscleCell Signaling +15

Lipoprotein lipase suppression in 3T3-L1 cells by an endotoxin-induced mediator from exudate cells.

Masanobu Kawakami, P H Pekala, M. Daniel Lane, +1

Proceedings of the National Academy of Sciences

Lipid PeroxidationExudate CellsCellular PhysiologyOxidative StressInflammation +16

Insulin responsiveness in skeletal muscle is determined by glucose transporter (Glut4) protein level

Marialice Kern, James A. Wells, Jacqueline M. Stephens, +5

Biochemical Journal

Glucose TransportMetabolic SyndromeMuscle FunctionKinesiologyBody Composition +12

Transcriptional repression of the C/EBP-alpha and GLUT4 genes in 3T3-L1 adipocytes by tumor necrosis factor-alpha. Regulations is coordinate and independent of protein synthesis.

Jacqueline M. Stephens, P H Pekala

Journal of Biological Chemistry

ImmunologyInsulin SignalingProtein SynthesisMetabolic SyndromeTranscriptional Regulation +15

Selective inhibition of synthesis of enzymes for de novo fatty acid biosynthesis by an endotoxin-induced mediator from exudate cells.

P H Pekala, Masanobu Kawakami, Caroline Angus, +2

Proceedings of the National Academy of Sciences

Endotoxin-induced MediatorBiosynthesisEngineeringLipid SynthesisBiochemistry +12

Regulation of hexose transport in aortic endothelial cells by vascular permeability factor and tumor necrosis factor-alpha, but not by insulin.

P H Pekala, Marguerite Marlow, Deborah M. Heuvelman, +1

Journal of Biological Chemistry

Hexose TransportImmunologyCellular PhysiologyInsulin SignalingInflammation +17

Effect of endotoxin-induced monokines on glucose metabolism in the muscle cell line L6.

M D Lee, William Vine, P H Pekala, +1

Proceedings of the National Academy of Sciences

Hexose TransportEndotoxin-induced MonokinesMetabolic RemodelingCellular PhysiologyHexose Transporters +18

The growth factor-like effects of tumor necrosis factor-alpha. Stimulation of glucose transport activity and induction of glucose transporter and immediate early gene expression in 3T3-L1 preadipocytes

Peter Cornelius, Melissa Marlowe, M D Lee, +1

Journal of Biological Chemistry

ImmunologyPathologyCell ProliferationTnf Signal TransductionCell Growth +16