Mutation of <i>BCL-6</i> Gene in Normal B Cells by the Process of Somatic Hypermutation of Ig Genes

Hong Ming Shen, Andrew Peters, Beverly W. Baron, +2

Science

Activation-induced cytidine deaminase (AID) can target both DNA strands when the DNA is supercoiled

Hong Ming Shen, Ursula Storb

Proceedings of the National Academy of Sciences

Somatic Hypermutation and Class Switch Recombination in Msh6−/−Ung−/− Double-Knockout Mice

Hong Ming Shen, Atsushi Tanaka, Grazyna Bozek, +2

The Journal of Immunology

The E Box Motif CAGGTG Enhances Somatic Hypermutation without Enhancing Transcription

Nancy Michael, Hong Ming Shen, Simonne Longerich, +3

Immunity

Transcriptional RegulationSomatic Cell GeneticsGeneticsGene RegulationEnhancing Transcription +5

The activation-induced cytidine deaminase (AID) efficiently targets DNA in nucleosomes but only during transcription

Hong Ming Shen, Michael G. Poirier, Michael J. Allen, +4

The Journal of Experimental Medicine

GeneticsMolecular BiologyTranscription AidEpigeneticsTranscriptional Regulation +15

Targeting of the Activation-Induced Cytosine Deaminase Is Strongly Influenced by the Sequence and Structure of the Targeted DNA

Hong Ming Shen, Sarayu Ratnam, Ursula Storb

Molecular and Cellular Biology

GeneticsGenomic MechanismMolecular BiologyEpigeneticsTranscriptional Regulation +18

Attracting AID to targets of somatic hypermutation

Atsushi Tanaka, Hong Ming Shen, Sarayu Ratnam, +2

The Journal of Experimental Medicine

ChromatinSystems BiologySignal TransductionRepresentation TheorySomatic Hypermutation +11

Somatic hypermutation: Processivity of the cytosine deaminase AID and error-free repair of the resulting uracils

Ursula Storb, Hong Ming Shen, Dan L. Nicolae

Cell Cycle

GeneticsMolecular BiologyCytoskeletonEpigeneticsKnockout Mouse +14

The inactivation of the XP-C gene does not affect somatic hypermutation or class switch recombination of immunoglobulin genes

Hong Ming Shen, David L. Cheo, Errol C. Friedberg, +1

Molecular Immunology

HistocompatibilityImmunogeneticsSomatic HypermutationGeneticsImmunology +8

Expression of AID transgene is regulated in activated B cells but not in resting B cells and kidney

Hong Ming Shen, Grazyna Bozek, Carl A. Pinkert, +4

Molecular Immunology

Activated B CellsAid TransgeneCell RegulationLymphocyte DevelopmentImmunology +7