M. F. G. STEVENS

Antitumor activity and pharmacokinetics in mice of 8-carbamoyl-3-methyl-imidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one (CCRG 81045; M & B 39831), a novel drug with potential as an alternative to dacarbazine.

M. F. G. STEVENS, J A Hickman, S P Langdon et al. · PubMed · 1987 · 390 citations

Antitumor Activity, Pharmacotherapy, Metronomic Chemotherapy +17

Cancer Research Campaign phase II trial of temozolomide in metastatic melanoma.

N. M. Bleehen, E.S. Newlands, Siow Ming Lee et al. · Journal of Clinical Oncology · 1995 · 282 citations

Temozolomide: A new oral cytotoxic chemotherapeutic agent with promising activity against primary brain tumours

S.M. O'Reilly, E.S. Newlands, M Brampton et al. · European Journal of Cancer · 1993 · 277 citations

Neuro-oncology, Promising Activity, Medicine +10

Telomere uncapping by the G-quadruplex ligand RHPS4 inhibits clonogenic tumour cell growth in vitro and in vivo consistent with a cancer stem cell targeting mechanism

Pornima Phatak, J.C. Cookson, Fangping Dai et al. · British Journal of Cancer · 2007 · 188 citations · Full text

PARP1 is activated at telomeres upon G4 stabilization: possible target for telomere-based therapy

Erica Salvati, Marco Scarsella, Manuela Porru et al. · Oncogene · 2010 · 122 citations · Full text

Signal Transduction, Telomere-based Therapy, Molecular Biology +5