Manuela Porru

Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds

J. Zimmer, Eliana MC Tacconi, Cecilia Folio et al. · Molecular Cell · 2015 · 256 citations · Full text

BRCA2 abrogation triggers innate immune responses potentiated by treatment with PARP inhibitors

Timo Reisländer, Emilia Puig Lombardi, Florian J. Groelly et al. · Nature Communications · 2019 · 177 citations · Full text

Stabilization of quadruplex DNA perturbs telomere replication leading to the activation of an ATR-dependent ATM signaling pathway

Angela Rizzo, Erica Salvati, Manuela Porru et al. · Nucleic Acids Research · 2009 · 171 citations · Full text

Selective G4 Ligands, Chromatin, Genome Instability +14

PARP1 is activated at telomeres upon G4 stabilization: possible target for telomere-based therapy

Erica Salvati, Marco Scarsella, Manuela Porru et al. · Oncogene · 2010 · 122 citations · Full text

Signal Transduction, Telomere-based Therapy, Molecular Biology +5

Restoring p53 active conformation by zinc increases the response of mutant p53 tumor cells to anticancer drugs

Rosa Puca, Lavinia Nardinocchi, Manuela Porru et al. · Cell Cycle · 2011 · 117 citations · Full text

Mutant P53, Functional Conformation, Medicine +14