Akira Okazaki

Comparison of biological activity among nonfucosylated therapeutic IgG1 antibodies with three different N-linked Fc oligosaccharides: the high-mannose, hybrid, and complex types

Yutaka Kanda, Tsuyoshi Yamada, Katsuhiro Mori et al. · Glycobiology · 2006 · 375 citations

Pharmacy, Biochemistry, Immunology +17

Fucose Depletion from Human IgG1 Oligosaccharide Enhances Binding Enthalpy and Association Rate Between IgG1 and FcγRIIIa

Akira Okazaki, Emi Shoji-Hosaka, Kazuyasu Nakamura et al. · Journal of Molecular Biology · 2004 · 337 citations

Life Sciences, Biochemistry, Immunology +13

Establishment of a GDP-mannose 4,6-dehydratase (GMD) knockout host cell line: A new strategy for generating completely non-fucosylated recombinant therapeutics

Yutaka Kanda, Harue Imai-Nishiya, Reiko Kuni‐Kamochi et al. · Journal of Biotechnology · 2007 · 123 citations

Life Sciences, Biochemistry, Molecular Biology +9

The N-linked oligosaccharide at Fc RIIIa Asn-45: an inhibitory element for high Fc RIIIa binding affinity to IgG glycoforms lacking core fucosylation

Mami Shibata‐Koyama, S. Iida, Akira Okazaki et al. · Glycobiology · 2008 · 117 citations · Full text

Pharmacy, Biochemistry, Immunology +17

Non-fucosylated therapeutic antibodies: the next generation of therapeutic antibodies

Katsuhiro Mori, Shigeru Iida, Naoko Yamane‐Ohnuki et al. · Cytotechnology · 2007 · 100 citations · Full text

Pharmacy, Medicinal Chemistry, Molecular Pharmaceutics +16