J. Gut

The molecular mechanisms of two common polymorphisms of drug oxidation-evidence for functional changes in cytochrome P-450 isozymes catalysing bufuralol and mephenytoin oxidation

Urs Meyer, J. Gut, Thomas Kronbach et al. · Xenobiotica · 1986 · 130 citations

Medicine, Biochemistry, Pharmacology +17

Debrisoquine/sparteine-type polymorphism of drug oxidation. Purification and characterization of two functionally different human liver cytochrome P-450 isozymes involved in impaired hydroxylation of the prototype substrate bufuralol.

J. Gut, Therese Catin, Pierre Dayer et al. · Journal of Biological Chemistry · 1986 · 111 citations · Full text

Medicine, Biochemistry, Pharmacology +16

Rotation of cytochrome P-450. I. Investigations of protein-protein interactions of cytochrome P-450 in phospholipid vesicles and liver microsomes.

Suguru Kawato, J. Gut, Richard J. Cherry et al. · Journal of Biological Chemistry · 1982 · 96 citations · Full text

Natural Sciences, Biochemistry, Biophysics +17

Rotation of cytochrome P-450. II. Specific interactions of cytochrome P-450 with NADPH-cytochrome P-450 reductase in phospholipid vesicles.

J. Gut, Christoph Richter, Richard J. Cherry et al. · Journal of Biological Chemistry · 1982 · 76 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16

Characterization of a common genetic defect of cytochrome P-450 function (debrisoquine-sparteine type polymorphism) — Increased michaelis constant (km) and loss of stereoselectivity of bufuralol 1′-hydroxylation in poor metabolizers

Pierre Dayer, Rodolfo Gasser, J. Gut et al. · Biochemical and Biophysical Research Communications · 1984 · 66 citations

Life Sciences, Biochemistry, Genetics +13