Michelle A. Hughes

A Death Effector Domain Chain DISC Model Reveals a Crucial Role for Caspase-8 Chain Assembly in Mediating Apoptotic Cell Death

Laura S. Dickens, Robert S. Boyd, Rebekah Jukes‐Jones et al. · Molecular Cell · 2012 · 335 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Co-operative and Hierarchical Binding of c-FLIP and Caspase-8: A Unified Model Defines How c-FLIP Isoforms Differentially Control Cell Fate

Michelle A. Hughes, Ian Powley, Rebekah Jukes‐Jones et al. · Molecular Cell · 2016 · 258 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +17

Fas-associated Death Domain Protein and Caspase-8 Are Not Recruited to the Tumor Necrosis Factor Receptor 1 Signaling Complex during Tumor Necrosis Factor-induced Apoptosis

Nicholas W. Harper, Michelle A. Hughes, Marion MacFarlane et al. · Journal of Biological Chemistry · 2003 · 209 citations · Full text

Life Sciences, Cell Biology, Immunology +17

Reconstitution of the Death-Inducing Signaling Complex Reveals a Substrate Switch that Determines CD95-Mediated Death or Survival

Michelle A. Hughes, Nicholas W. Harper, Michael Butterworth et al. · Molecular Cell · 2009 · 178 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +16

Caspase-10 Negatively Regulates Caspase-8-Mediated Cell Death, Switching the Response to CD95L in Favor of NF-κB Activation and Cell Survival

Sebastian Horn, Michelle A. Hughes, Ramon Schilling et al. · Cell Reports · 2017 · 109 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +17