Concepedia

Reconstitution of the Death-Inducing Signaling Complex Reveals a Substrate Switch that Determines CD95-Mediated Death or Survival

Michelle A. Hughes, Nicholas W. Harper, Michael Butterworth, Kelvin Cain, Gerald M. Cohen, Marion MacFarlane

Molecular Cell · 2009 · 178 citations · 24 references

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References

24

FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex

Marta Muzio, Arul M. Chinnaiyan, Frank Kischkel et al. · Cell · 1996 · 3.1K citations · Full text

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Involvement of MACH, a Novel MORT1/FADD-Interacting Protease, in Fas/APO-1- and TNF Receptor–Induced Cell Death

Mark Boldin, Tanya Goncharov, Yury V Goltseve et al. · Cell · 1996 · 2.3K citations · Full text

, , +12

Cytotoxicity‐dependent APO‐1 (Fas/CD95)‐associated proteins form a death‐inducing signaling complex (DISC) with the receptor.

Frank Kischkel, Stefan Hellbardt, Iris Behrmann et al. · The EMBO Journal · 1995 · 2.1K citations · Full text

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FLICE is activated by association with the CD95 death‐inducing signaling complex (DISC)

Jan Paul Medema · The EMBO Journal · 1997 · 1.2K citations · Full text

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An Induced Proximity Model for Caspase-8 Activation

Marta Muzio, Brent R. Stockwell, Henning R. Stennicke et al. · Journal of Biological Chemistry · 1998 · 1K citations · Full text

, , +15