Designed heterodimerizing leucine zippers with a ranger of pIs and stabilities up to 10⁻¹⁵ M

Jonathan R. Moll, Sergei B. Ruvinov, I Pastan, +1

Protein Science

EngineeringPhysicsBiomolecular ScienceProtein FoldingNatural Sciences +13

Preclinical development of a recombinant toxin containing circularly permuted interleukin 4 and truncated Pseudomonas exotoxin for therapy of malignant astrocytoma.

Raj K. Puri, Dave S.�B. Hoon, Pamela Leland, +4

PubMed

ToxinologyHigh-affinity Il-4rImmunologyPathologyImmune System +17

Complete regression of established human glioblastoma tumor xenograft by interleukin-4 toxin therapy.

Syed R. Husain, N Behari, Robert J. Kreitman, +2

PubMed

Neuro-oncologyTumor BiologyCurative TherapyGliomaMedicine +13

Cytotoxic activity of disulfide-stabilized recombinant immunotoxin RFB4(dsFv)-PE38 (BL22) toward fresh malignant cells from patients with B-cell leukemias.

R. J. Kreitman, Inger Margulies, M Stetler-Stevenson, +3

PubMed

Hematological MalignancyCancer ImmunosurveillanceImmunotoxicologyMalignant Blood DisorderImmunology +13

Immunotoxins with increased activity against epidermal growth factor receptor vIII-expressing cells produced by antibody phage display.

Richard Beers, P. Chowdhury, Darell D. Bigner, +1

PubMed

Immune RegulationImmunologyImmunoeditingImmunologic MechanismImmunotherapy +15

Single-chain immunotoxin fusions between anti-tac and Pseudomonas exotoxin: Relative importance of the two toxin disulfide bonds

R. J. Kreitman, Janendra K. Batra, Saraswathy Seetharam, +3

Bioconjugate Chemistry

Immunotoxins that target an oncogenic mutant epidermal growth factor receptor expressed in human tumors.

Ian Lorimer, Carol J. Wikstrand, Surinder K. Batra, +2

PubMed

ImmunologyPathologyDeletion JunctionCancer BiologyGlioma +14

Pseudomonas exotoxin-based immunotoxins containing the antibody LL2 or LL2-Fab' induce regression of subcutaneous human B-cell lymphoma in mice.

Robert J. Kreitman, H. J. Hansen, Anastasia L. Jones, +3

PubMed

ImmunotoxicologyImmunologyPathologyImmunologic MechanismAntibody Ll2 +15

Antitumor activity of a transforming growth factor alpha-Pseudomonas exotoxin fusion protein (TGF-alpha-PE40).

Lee H. Pai, Maria Gallo, David J. FitzGerald, +1

PubMed

Microbial ToxinAntitumor ActivityImmunologyPseudomonas ToxinPathology +10

A new vector using the human multidrug resistance gene as a selectable marker enables overexpression of foreign genes in eukaryotic cells

Susan E. Kane, Diana H. Reinhard, C.Michael Fordis, +2

Gene

Gene TherapiesAntimicrobial Resistance GeneSelectable MarkerDrug ResistanceGenetics +10