I Pastan

Designed heterodimerizing leucine zippers with a ranger of pIs and stabilities up to 10⁻¹⁵ M

Jonathan R. Moll, Sergei B. Ruvinov, I Pastan et al. · Protein Science · 2001 · 151 citations · Full text

Engineering, Physics, Biomolecular Science +15

Preclinical development of a recombinant toxin containing circularly permuted interleukin 4 and truncated Pseudomonas exotoxin for therapy of malignant astrocytoma.

Raj K. Puri, Dave S.�B. Hoon, Pamela Leland et al. · PubMed · 1996 · 112 citations

Toxinology, High-affinity Il-4r, Immunology +19

Complete regression of established human glioblastoma tumor xenograft by interleukin-4 toxin therapy.

Syed R. Husain, N Behari, Robert J. Kreitman et al. · PubMed · 1998 · 94 citations

Neuro-oncology, Tumor Biology, Curative Therapy +15

Cytotoxic activity of disulfide-stabilized recombinant immunotoxin RFB4(dsFv)-PE38 (BL22) toward fresh malignant cells from patients with B-cell leukemias.

R. J. Kreitman, Inger Margulies, M Stetler-Stevenson et al. · PubMed · 2000 · 87 citations

Hematological Malignancy, Cancer Immunosurveillance, Immunotoxicology +15

Immunotoxins with increased activity against epidermal growth factor receptor vIII-expressing cells produced by antibody phage display.

Richard Beers, P. Chowdhury, Darell D. Bigner et al. · PubMed · 2000 · 76 citations

Immune Regulation, Immunology, Immunoediting +17