Isolation of a high-affinity stable single-chain Fv specific for mesothelin from DNA-immunized mice by phage display and construction of a recombinant immunotoxin with anti-tumor activity

Partha S. Chowdhury, Jaye L. Viner, Richard Beers, +1

Proceedings of the National Academy of Sciences

An immunotoxin with greatly reduced immunogenicity by identification and removal of B cell epitopes

Masanori Onda, Richard Beers, Laiman Xiang, +3

Proceedings of the National Academy of Sciences

Adaptive Immune SystemHumoral ResponseImmunologyImmunologic MechanismAntigen Processing +17

Improved cytotoxic activity toward cell lines and fresh leukemia cells of a mutant anti-CD22 immunotoxin obtained by antibody phage display.

Giuliana Salvatore, Richard Beers, Inger Margulies, +2

PubMed

ImmunotoxicologyImmunologyImmunologic MechanismImmunotherapyPlant Toxins +14

Recombinant immunotoxins specific for a mutant epidermal growth factor receptor: Targeting with a single chain antibody variable domain isolated by phage display

Ian Lorimer, Andrea Keppler‐Hafkemeyer, Richard Beers, +3

Proceedings of the National Academy of Sciences

Human GrowthImmunologyPathologyCancer BiologyPhage Display +16

The MyoD family of myogenic factors is regulated by electrical activity: isolation and characterization of a mouse Myf-5 cDNA

Andrés Buonanno, Lynne Apone, María I. Morasso, +3

Nucleic Acids Research

Muscle FunctionMolecular RegulationCellular PhysiologyElectrical ActivitySkeletal Muscle +18

Differential Cellular Internalization of Anti-CD19 and -CD22 Immunotoxins Results in Different Cytotoxic Activity

Xing Du, Richard Beers, David Fitzgerald, +1

Cancer Research

Recombinant immunotoxin for cancer treatment with low immunogenicity by identification and silencing of human T-cell epitopes

Ronit Mazor, Jaime Eberle-Singh, Xiaobo Hu, +11

Proceedings of the National Academy of Sciences

Characterization of the B Cell Epitopes Associated with a Truncated Form of <i>Pseudomonas</i> Exotoxin (PE38) Used to Make Immunotoxins for the Treatment of Cancer Patients

Masanori Onda, Satoshi Nagata, David Fitzgerald, +9

The Journal of Immunology

Recombinant immunotoxin against B-cell malignancies with no immunogenicity in mice by removal of B-cell epitopes

Masanori Onda, Richard Beers, Laiman Xiang, +4

Proceedings of the National Academy of Sciences

B-cell MalignanciesHumoral ResponseImmunologyImmunodominancePathology +15

A Recombinant Immunotoxin against the Tumor-Associated Antigen Mesothelin Reengineered for High Activity, Low Off-Target Toxicity, and Reduced Antigenicity

John E. Weldon, Laiman Xiang, Jingli Zhang, +5

Molecular Cancer Therapeutics

Reengineered Ss1pEngineeringImmunotoxicologyImmunologyImmunotherapeutics +18