R. J. Kreitman

Cytotoxic activity of disulfide-stabilized recombinant immunotoxin RFB4(dsFv)-PE38 (BL22) toward fresh malignant cells from patients with B-cell leukemias.

R. J. Kreitman, Inger Margulies, M Stetler-Stevenson et al. · PubMed · 2000 · 87 citations

Medicine, Immunology, Oncology +16

Immunotoxin-mediated conditional disruption of specific neurons in transgenic mice.

Kazuto Kobayashi, Shinya Morita, Hirohide Sawada et al. · Proceedings of the National Academy of Sciences · 1995 · 82 citations

Life Sciences, Neurobiology, Neuroscience +13

Single-chain immunotoxin fusions between anti-tac and Pseudomonas exotoxin: Relative importance of the two toxin disulfide bonds

R. J. Kreitman, Janendra K. Batra, Saraswathy Seetharam et al. · Bioconjugate Chemistry · 1993 · 73 citations

Life Sciences, Immunology, Microbiology +13

A wide range of human cancers express interleukin 4 (IL4) receptors that can be targeted with chimeric toxin composed of IL4 and Pseudomonas exotoxin

Waldemar Debinski, Raj K. Puri, R. J. Kreitman et al. · Journal of Biological Chemistry · 1993 · 70 citations · Full text

Medicine, Immunology, Oncology +9

Lowering the isoelectric point of the Fv portion of recombinant immunotoxins leads to decreased nonspecific animal toxicity without affecting antitumor activity.

Masanori Onda, Satoshi Nagata, Yasuo Tsutsumi et al. · PubMed · 2001 · 68 citations

Life Sciences, Biomolecular Engineering, Immunology +12