The histone deacetylase inhibitor and chemotherapeutic agent suberoylanilide hydroxamic acid (SAHA) induces a cell-death pathway characterized by cleavage of Bid and production of reactive oxygen species

Astrid A. Ruefli, Michael J. Ausserlechner, David Bernhard, +5

Proceedings of the National Academy of Sciences

Histone Deacetylase InhibitorApoptosisCell DeathReactive Oxygen SpeciesRedox Biology +14

Bcl-2 and Bcl-XL antagonize the mitochondrial dysfunction preceding nuclear apoptosis induced by chemotherapeutic agents.

Didier Decaudin, Stephan Geley, Tamara Hirsch, +5

PubMed

Chemoprevention StrategyMitochondrial DysfunctionApoptosisImmunologyCell Death +15

CLP1 links tRNA metabolism to progressive motor-neuron loss

Toshikatsu Hanada, Stefan Weitzer, Barbara Mair, +21

Nature

Trna MetabolismNeurotransmissionMolecular NeurobiologyCentral Nervous SystemNeuroscience

A Molecular Function Map of Ewing's Sarcoma

Maximilian Kauer, Jozef Ban, Reinhard Kofler, +3

PLoS ONE

Identification of a B cell differentiation factor(s) spontaneously produced by proliferating T cells in murine lupus strains of the lpr/lpr genotype.

Gérald J. Prud’homme, C L Park, Terry M. Fieser, +3

The Journal of Experimental Medicine

Lymphocyte DevelopmentImmunologyImmunologic MechanismT CellsImmunotherapy +16

Resveratrol, a tumor‐suppressive compound from grapes, induces apoptosis via a novel mitochondrial pathway controlled by Bcl‐2

Inge Tinhofer, David Bernhard, Monika Senfter, +6

The FASEB Journal

Drug-induced apoptosis is associated with enhanced Fas (Apo-1/CD95) ligand expression but occurs independently of Fas (Apo-1/CD95) signaling in human T-acute lymphatic leukemia cells.

Andreas Villunger, Alexander Egle, Marion Kos, +4

PubMed

Fasl ProteinApoptosisImmunologyCell DeathImmunotherapy +16

Resveratrol causes arrest in the S-phase prior to Fas-independent apoptosis in CEM-C7H2 acute leukemia cells

David Bernhard, Ingeborg Tinhofer, Martin Tonko, +5

Cell Death and Differentiation

Fas-independent ApoptosisChemoprevention StrategyMedicineApoptosisCell Death +6

The thiol crosslinking agent diamide overcomes the apoptosis-inhibitory effect of Bcl-2 by enforcing mitochondrial permeability transition

Naoufal Zamzami, Isabel Marzo, Santos A. Susín, +6

Oncogene

MitophagyMitochondrial FunctionBiochemistryMedicineNatural Sciences +11

Identification of glucocorticoid-response genes in children with acute lymphoblastic leukemia

Stefan Schmidt, Johannes Rainer, Stefan Riml, +12

Blood