Structure guided design of a series of sphingosine kinase (SphK) inhibitors

Darin J. Gustin, Yihong Li, Matthew L. Brown, +24

Bioorganic & Medicinal Chemistry Letters

Combinatorial ChemistryMedicinal ChemistryBiochemistryNatural SciencesMedicine +7

Discovery of AB680: A Potent and Selective Inhibitor of CD73

Kenneth V. Lawson, Jarosław Kalisiak, Erick A. Lindsey, +23

Journal of Medicinal Chemistry

Identification and Characterization of a Non-retinoid Ligand for Retinol-binding Protein 4 Which Lowers Serum Retinol-binding Protein 4 Levels in Vivo

Alykhan Motani, Zhulun Wang, Marion Conn, +14

Journal of Biological Chemistry

Rbp4 LoweringRetinal TherapiesInsulin SignalingMetabolic SyndromeRetina +14

Sphingosine Kinase Activity Is Not Required for Tumor Cell Viability

Karen Rex, Shawn Jeffries, Matthew L. Brown, +22

PLoS ONE

Chemoprevention StrategyApoptosisCell DeathCancer BiologyTumor Biology +16

A Selective Prostaglandin E₂ Receptor Subtype 2 (EP2) Antagonist Increases the Macrophage-Mediated Clearance of Amyloid-Beta Plaques

Brian M. Fox, Hilary P. Beck, Philip M. Roveto, +11

Journal of Medicinal Chemistry

ImmunologyMacrophage-mediated ClearanceNeurochemical BiomarkersPharmacotherapyNeuroinflammation +17

Discovery and molecular basis of potent noncovalent inhibitors of fatty acid amide hydrolase (FAAH)

Xiaoshan Min, Stephen T. Thibault, Amy C. Porter, +11

Proceedings of the National Academy of Sciences

Identification of potent, noncovalent fatty acid amide hydrolase (FAAH) inhibitors

Darin J. Gustin, Zhihua Ma, Xiaoshan Min, +13

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryNoncovalent Fatty AcidAldehyde DehydrogenaseBiochemistryNatural Sciences +7

Investigation of collision‐induced dissociations involving odd‐electron ion formation under positive electrospray ionization conditions using accurate mass

Guifen Xu, Tom Huang, Jennifer Zhang, +3

Rapid Communications in Mass Spectrometry

EngineeringFragment Ion MassesOrganic ChemistryFree Radical FragmentationChemistry +17

Addressing PXR liabilities of phthalazine-based hedgehog/smoothened antagonists using novel pyridopyridazines

Jacob A. Kaizerman, Wade H. Aaron, Songzhu An, +17

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryDerivativesEngineeringPxr LiabilitiesMedicine +5

Discovery of Potent and Selective Methylenephosphonic Acid CD73 Inhibitors

Ehesan U. Sharif, Jarosław Kalisiak, Kenneth V. Lawson, +15

Journal of Medicinal Chemistry