Structural Insights and Biological Effects of Glycogen Synthase Kinase 3-specific Inhibitor AR-A014418

Ratan V. Bhat, Yafeng Xue, Stefan von Berg, +13

Journal of Biological Chemistry

A zebrafish model of tauopathy allows in vivo imaging of neuronal cell death and drug evaluation

Dominik Paquet, Ratan V. Bhat, Astrid Sydow, +8

Journal of Clinical Investigation

Cell DeathTauopathy AllowsCellular NeurobiologyTau ProteinAlzheimer's Disease +20

Discovery of Novel Potent and Highly Selective Glycogen Synthase Kinase-3β (GSK3β) Inhibitors for Alzheimer’s Disease: Design, Synthesis, and Characterization of Pyrazines

Stefan von Berg, Margareta Bergh, Sven Hellberg, +12

Journal of Medicinal Chemistry

Discovery of AZD3839, a Potent and Selective BACE1 Inhibitor Clinical Candidate for the Treatment of Alzheimer Disease

Fredrik Jeppsson, Susanna Eketjäll, Juliette Janson, +11

Journal of Biological Chemistry

<scp>AZD</scp>1080, a novel <scp>GSK</scp>3 inhibitor, rescues synaptic plasticity deficits in rodent brain and exhibits peripheral target engagement in humans

Biljana Georgievska, Johan Sandin, James Doherty, +12

Journal of Neurochemistry

Synaptic Plasticity DeficitsSynaptic TransmissionNeurotransmissionCellular NeurobiologySynaptic Signaling +24

Design and Synthesis of β-Site Amyloid Precursor Protein Cleaving Enzyme (BACE1) Inhibitors with in Vivo Brain Reduction of β-Amyloid Peptides

Britt‐Marie Swahn, Karin Kolmodin, Sofia Karlström, +23

Journal of Medicinal Chemistry

New Aminoimidazoles as β-Secretase (BACE-1) Inhibitors Showing Amyloid-β (Aβ) Lowering in Brain

Ylva Gravenfors, Jenny Viklund, Jan Blid, +17

Journal of Medicinal Chemistry

New AminoimidazolesNeurochemical BiomarkersPharmaceutical ChemistryPre-clinical PharmacologyMolecular Pharmacology +21

Benzoxazepines Achieve Potent Suppression of IL‐17 Release in Human T‐Helper 17 (T_H17) Cells through an Induced‐Fit Binding Mode to the Nuclear Receptor RORγ

Roine I. Olsson, Yafeng Xue, Stefan von Berg, +13

ChemMedChem

Aminoimidazoles as BACE-1 inhibitors: The challenge to achieve in vivo brain efficacy

Britt‐Marie Swahn, Jörg Holenz, Jacob Kihlström, +14

Bioorganic & Medicinal Chemistry Letters

MedicinePharmacologyBace-1 InhibitorsPharmacological AgentNeuropharmacology +8

Revisiting the peripheral sink hypothesis: inhibiting <scp>BACE</scp>1 activity in the periphery does not alter β‐amyloid levels in the <scp>CNS</scp>

Biljana Georgievska, Susanne Gustavsson, Johan Lundkvist, +10

Journal of Neurochemistry

Neurochemical BiomarkersSynaptic SignalingSocial SciencesNeuroinflammationAlzheimer's Disease +21