Structural Insights and Biological Effects of Glycogen Synthase Kinase 3-specific Inhibitor AR-A014418

Ratan V. Bhat, Yafeng Xue, Stefan von Berg, +13

Journal of Biological Chemistry

Discovery of Novel Potent and Highly Selective Glycogen Synthase Kinase-3β (GSK3β) Inhibitors for Alzheimer’s Disease: Design, Synthesis, and Characterization of Pyrazines

Stefan von Berg, Margareta Bergh, Sven Hellberg, +12

Journal of Medicinal Chemistry

Inhibition and catalysis of carbonic anhydrase

Anders Liljas, Kjell Erik Julius Håkansson, B Jönsson, +1

European Journal of Biochemistry

Inorganic ChemistryMedicinal ChemistryBioorganic ChemistryEngineeringBiochemistry +12

Exploitation of structural and regulatory diversity in glutamate racemases

T. Lundqvist, Stewart L. Fisher, Günther Kern, +6

Nature

Glutamate RacemasesNatural SciencesGeneticsGene StructureMolecular Biology +4

Crystal structure of carbonic anhydrase from Neisseria gonorrhoeae and its complex with the inhibitor acetazolamide

Shenghua Huang, Yafeng Xue, A.E. Sauer-Eriksson, +3

Journal of Molecular Biology

Crystal StructureBiochemistryNatural SciencesProtein X-ray CrystallographyBioorganometallic Chemistry +6

Importance of the conserved active‐site residues Try7, Glu106 and Thr199 for the catalytic function of human carbonic anhydrase II

Zhiwei Liang, Yafeng Xue, Gity Behravan, +2

European Journal of Biochemistry

Crystallographic analysis of Thr‐200 → His human carbonic anhydrase II and its complex with the substrate, HCO

Yafeng Xue, Jukka Vidgren, L.A. Svensson, +3

Proteins Structure Function and Bioinformatics

Interfering with the inhibitory mechanism of serpins: crystal structure of a complex formed between cleaved plasminogen activator inhibitor type 1 and a reactive-centre loop peptide

Yafeng Xue, Petter Björquist, Tord Inghardt, +4

Structure

Inhibitory MechanismCrystal StructureProtein AssemblyBiochemistryNatural Sciences +4

Hit-to-lead studies: the discovery of potent, orally active, thiophenecarboxamide IKK-2 inhibitors

Andrew Baxter, Steve Brough, Anne Cooper, +14

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryThiophenecarboxamide Ikk-2 InhibitorsHit IdentificationDrug TargetBiochemistry +9

Crystal structure of spinach chloroplast fructose-1,6-bisphosphatase at 2.8 .ANG. resolution

Vincent Villeret, Shenghua Huang, Yiping Zhang, +2

Biochemistry