Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq

Itay Tirosh, Benjamin Izar, Sanjay M. Prakadan, +33

Science

Melanoma TumorsImmunologyBiological MicroenvironmentsTumor BiologyOncology +17

Single-cell transcriptomics reveals bimodality in expression and splicing in immune cells

Alex K. Shalek, Rahul Satija, Xian Adiconis, +15

Nature

Immune CellsFunctional GenomicsSingle Cell SequencingMedicineImmunology +11

Single-cell RNA-seq reveals dynamic paracrine control of cellular variation

Alex K. Shalek, Rahul Satija, Joe Shuga, +19

Nature

Single Cell SequencingMedicineRna BiologyRna SequencingSingle-cell Genomics +4

Dynamic regulatory network controlling TH17 cell differentiation

Nir Yosef, Alex K. Shalek, Jellert T. Gaublomme, +20

Nature

Whole-exome sequencing of circulating tumor cells provides a window into metastatic prostate cancer

Jens G. Lohr, Viktor A. Adalsteinsson, Kristian Cibulskis, +35

Nature Biotechnology

Dynamic profiling of the protein life cycle in response to pathogens

Marko Jovanović, Michael S. Rooney, Philipp Mertins, +17

Science

Strain-specific activation of the NF-κB pathway by GRA15, a novel <i>Toxoplasma gondii</i> dense granule protein

Emily E. Rosowski, Diana Lu, Lindsay Julien, +4

The Journal of Experimental Medicine

Strain-specific ActivationInnate Immune SystemImmunologyImmune RegulationCell Death +19

STAG2 loss rewires oncogenic and developmental programs to promote metastasis in Ewing sarcoma

Biniam Adane, Gabriela Alexe, Bo Kyung A. Seong, +25

Cancer Cell

Ewing SarcomaMedicinePathologyCancer GeneticsStag2 Loss +5

Admixture and recombination among <i>Toxoplasma gondii</i> lineages explain global genome diversity

Samuel S. Minot, Mariane B. Melo, Fugen Li, +4

Proceedings of the National Academy of Sciences

Parasitic DiseaseComparative GenomicsGeneticsPathologyMolecular Genetics +23

Toxoplasma gondii Rhoptry 16 Kinase Promotes Host Resistance to Oral Infection and Intestinal Inflammation Only in the Context of the Dense Granule Protein GRA15

Kirk D.C. Jensen, Kenneth H. Hu, Ryan J. Whitmarsh, +6

Infection and Immunity