Purification of topoisomerase II from amsacrine-resistant P388 leukemia cells. Evidence for two forms of the enzyme.

F H Drake, JP Zimmerman, F L McCabe, +7

Journal of Biological Chemistry

Cellular EnzymologyBiochemistryTopoisomerase IiNatural SciencesMedicine +9

Nonproductive Rearrangement of DNA Topoisomerase I and II Genes: Correlation With Resistance to Topoisomerase Inhibitors

K. B. Tan, Michael R. Mattern, W.-K. Eng, +2

JNCI Journal of the National Cancer Institute

Synergistic cell killing by ionizing radiation and topoisomerase I inhibitor topotecan (SK&F 104864).

Michael R. Mattern, G A Hofmann, F L McCabe, +1

PubMed

Radiation EffectCell DeathP388 CellsF 104864Radiation Biology +14

Development of a stable camptothecin-resistant subline of P388 leukemia with reduced topoisomerase I content.

Wai-Kwong Eng, F L McCabe, K. B. Tan, +5

Molecular Pharmacology

Pharmacokinetics and pharmacodynamics of topotecan in patients with advanced cancer.

L B Grochow, Eric K. Rowinsky, Randall S. Johnson, +7

Drug Metabolism and Disposition

In vitro and in vivo effects of clinically important camptothecin analogues on multidrug-resistant cells.

Michael R. Mattern, G A Hofmann, Rodd Polsky, +3

PubMed

Cellular PharmacologyCertain Cpt AnaloguesPharmacotherapyAntimicrobial ChemotherapyToxicological Mechanism +18

Camptothecin hyper-resistant P388 cells: drug-dependent reduction in topoisomerase I content.

Richard Woessner, Wai-Kwong Eng, G A Hofmann, +6

PubMed

Molecular PharmacologyMedicineApoptosisImmunologyCell Death +12

In vivo development and in vitro characterization of a subclone of murine P388 leukemia resistant to bis(diphenylphosphine)ethane.

Glenn D. Hoke, F L McCabe, Leo F. Faucette, +7

Molecular Pharmacology

Synthesis of flavone-8-carboxylic acid analogues as potential antitumor agents

SJ Cutler, F. M. El-kabbani, Charlene Keane, +4

European Journal of Medicinal Chemistry

Medicinal ChemistryMedicinePhytochemicalFlavone-8-carboxylic Acid AnaloguesAnti-cancer Agent +2