Wai-Kwong Eng

Evidence that DNA topoisomerase I is necessary for the cytotoxic effects of camptothecin.

Wai-Kwong Eng, Leo F. Faucette, Richard K. Johnson et al. · Molecular Pharmacology · 1988 · 322 citations

Life Sciences, Genetics, Molecular Biology +17

Dominant Missense Mutations in a Novel Yeast Protein related to Mammalian Phosphatidylinositol 3-Kinase and VPS34 Abrogate Rapamycin Cytotoxicity

Robert Cafferkey, Peter R. Young, Megan M. McLaughlin et al. · Molecular and Cellular Biology · 1993 · 276 citations · Full text

Life Sciences, Molecular Biology, Molecular Genetics +15

Dominant missense mutations in a novel yeast protein related to mammalian phosphatidylinositol 3-kinase and VPS34 abrogate rapamycin cytotoxicity.

Robert Cafferkey, Peter R. Young, Megan M. McLaughlin et al. · Molecular and Cellular Biology · 1993 · 194 citations

Life Sciences, Molecular Biology, Molecular Genetics +15

Development of a stable camptothecin-resistant subline of P388 leukemia with reduced topoisomerase I content.

Wai-Kwong Eng, F L McCabe, K. B. Tan et al. · Molecular Pharmacology · 1990 · 127 citations

Medicine, Oncology, Pharmacology +14

Mapping of the Active Site Tyrosine of Eukaryotic DNA Topoisomerase I

Wai-Kwong Eng, Subrata Pandit, Rolf Sternglanz · Journal of Biological Chemistry · 1989 · 93 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +10