Leo F. Faucette

Synthesis of water-soluble (aminoalkyl)camptothecin analogs: inhibition of topoisomerase I and antitumor activity

William D. Kingsbury, Jeffrey C. Boehm, Dalia R. Jakas et al. · Journal of Medicinal Chemistry · 1991 · 516 citations

Pharmaceutical Science, Antitumor Activity, Altmetric Attention Score +16

Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway

Priya Chaturvedi, Wai K Eng, Yuan Zhu et al. · Oncogene · 1999 · 423 citations

Chromatin, Genome Instability, Cell Regulation +8

Evidence that DNA topoisomerase I is necessary for the cytotoxic effects of camptothecin.

Wai-Kwong Eng, Leo F. Faucette, Richard K. Johnson et al. · Molecular Pharmacology · 1988 · 321 citations

Evaluation of the in vivo antitumor activity and in vitro cytotoxic properties of auranofin, a coordinated gold compound, in murine tumor models.

Christopher K. Mirabelli, Randall K. Johnson, Chiu Mei Sung et al. · PubMed · 1985 · 296 citations

Chemoprevention Strategy, Coordinated Gold Compound, Pharmacotherapy +17

Dominant Missense Mutations in a Novel Yeast Protein related to Mammalian Phosphatidylinositol 3-Kinase and VPS34 Abrogate Rapamycin Cytotoxicity

Robert Cafferkey, Peter R. Young, Megan M. McLaughlin et al. · Molecular and Cellular Biology · 1993 · 276 citations · Full text

Fungal Cell Biology, Genetics, Cell Death +17