Pharmacologic Activation of PKM2 Slows Lung Tumor Xenograft Growth

K. Mark Parnell, Jason M. Foulks, Rebecca N. Nix, +16

Molecular Cancer Therapeutics

4-[4-[(2-Hydroxybenzoyl)amino]phenyl]butyric Acid as a Novel Oral Delivery Agent for Recombinant Human Growth Hormone

Andrea Leone‐Bay, Koc-Kan Ho, Rajesh Agarwal, +11

Journal of Medicinal Chemistry

Medicinal ChemistryGastrointestinal Peptide HormonePharmaceutical ScienceGrowth HormoneBiochemistry +10

Discovery of 3-(trifluoromethyl)-1H-pyrazole-5-carboxamide activators of the M2 isoform of pyruvate kinase (PKM2)

Yong Xu, Xiaohui Liu, Michael A. Saunders, +11

Bioorganic & Medicinal Chemistry Letters

Pharmaceutical ChemistryBiochemistryMedicineNatural SciencesMechanism Of Action +6

Small molecule biaryl FSH receptor agonists. Part 2: Lead optimization via parallel synthesis

Tao Guo, Anton E.P. Adang, Guizhen Dong, +12

Bioorganic & Medicinal Chemistry Letters

Drug TargetFunctional SelectivityMedicineDrug DiscoveryRational Drug Design +6

Small molecule biaryl FSH receptor agonists. Part 1

Tao Guo, Anton E.P. Adang, Roland E. Dolle, +13

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyMolecular PhysiologySignal TransductionBiochemistryG Protein-coupled Receptor +6

Nonpeptidergic Allosteric Antagonists Differentially Bind to the CXCR2 Chemokine Receptor

Petra de Kruijf, Jane van Heteren, Herman D. Lim, +11

Journal of Pharmacology and Experimental Therapeutics

Discovery of 4-phenyl-2-phenylaminopyridine based TNIK inhibitors

Koc-Kan Ho, K. Mark Parnell, Yi Yuan, +8

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryMedicineTnik InhibitorsRational Drug DesignDrug Development +2

Imidazolylpyrimidine based CXCR2 chemokine receptor antagonists

Koc-Kan Ho, Douglas S. Auld, Adolph C. Bohnstedt, +21

Bioorganic & Medicinal Chemistry Letters

MedicineMechanism Of ActionPharmacological AgentPharmacotherapyNon-peptide Ligand +2

Eicosanoid regulation of debris-stimulated metastasis

Jianjun Deng, Haixia Yang, Victoria M. Haak, +13

Proceedings of the National Academy of Sciences

Structure–activity studies of a novel series of isoxazole-3-carboxamide derivatives as TRPV1 antagonists

Ronald Palin, Lynn Abernethy, Nasrin Ansari, +27

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyIsoxazole-3-carboxamide DerivativesStructure–activity StudiesBiochemistryMedicine +6