Preclinical Profile of AB-423, an Inhibitor of Hepatitis B Virus Pregenomic RNA Encapsidation

Nagraj Mani, Andrew G. Cole, Janet R. Phelps, +27

Antimicrobial Agents and Chemotherapy

Synthesis and Biological Evaluation of Pyrazolo[1,5-<i>a</i>]pyrimidine Compounds as Potent and Selective Pim-1 Inhibitors

Yong Xu, Benjamin Brenning, Steven G. Kultgen, +8

ACS Medicinal Chemistry Letters

Pim-1 InhibitorsSelective Pim-1 InhibitorsCellular PharmacologyPharmacotherapyLead Compound +19

Small molecule biaryl FSH receptor agonists. Part 2: Lead optimization via parallel synthesis

Tao Guo, Anton E.P. Adang, Guizhen Dong, +12

Bioorganic & Medicinal Chemistry Letters

Drug TargetFunctional SelectivityMedicineDrug DiscoveryRational Drug Design +6

Small molecule biaryl FSH receptor agonists. Part 1

Tao Guo, Anton E.P. Adang, Roland E. Dolle, +13

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyMolecular PhysiologySignal TransductionBiochemistryG Protein-coupled Receptor +6

Discovery of 4-phenyl-2-phenylaminopyridine based TNIK inhibitors

Koc-Kan Ho, K. Mark Parnell, Yi Yuan, +8

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryMedicineTnik InhibitorsRational Drug DesignDrug Development +2

Imidazolylpyrimidine based CXCR2 chemokine receptor antagonists

Koc-Kan Ho, Douglas S. Auld, Adolph C. Bohnstedt, +21

Bioorganic & Medicinal Chemistry Letters

MedicineMechanism Of ActionPharmacological AgentPharmacotherapyNon-peptide Ligand +2

Host Poly(A) Polymerases PAPD5 and PAPD7 Provide Two Layers of Protection That Ensure the Integrity and Stability of Hepatitis B Virus RNA

Fei Liu, Amy C. H. Lee, Fang Guo, +15

Journal of Virology

Preclinical characterization of AB-506, an inhibitor of HBV replication targeting the viral core protein

Nagraj Mani, Andrew G. Cole, Janet R. Phelps, +25

Antiviral Research

Viral ReplicationHbv ReplicationMolecular VirologyPathogenesisImmunology +5

Triazine and pyrimidine based ROCK inhibitors with efficacy in spontaneous hypertensive rat model

Koc-Kan Ho, James R. Beasley, Laura Belanger, +18

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryHypertensionMedicineAntihypertensive TherapyRock Inhibitors +5

2-(Aminomethyl)-benzamide-based glycine transporter type-2 inhibitors

Koc-Kan Ho, Kenneth C. Appell, John J. Baldwin, +13

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyMedicinal ChemistryBiochemistryMedicineNatural Sciences +4