Hitoshi Murai

Structure of the HIV-1 integrase catalytic domain complexed with an inhibitor: A platform for antiviral drug design

Yehuda Goldgur, Robert Craigie, Gerson H. Cohen et al. · Proceedings of the National Academy of Sciences · 1999 · 492 citations · Full text

Hiv Integrase, Molecular Biology, Antiviral Drug +17

Carbamoyl Pyridone HIV-1 Integrase Inhibitors 3. A Diastereomeric Approach to Chiral Nonracemic Tricyclic Ring Systems and the Discovery of Dolutegravir (S/GSK1349572) and (S/GSK1265744)

Brian A. Johns, Takashi Kawasuji, Jason G. Weatherhead et al. · Journal of Medicinal Chemistry · 2013 · 181 citations · Full text

Medicinal Chemistry, Bioorganic Chemistry, Biochemistry +15

Carbamoyl Pyridone HIV-1 Integrase Inhibitors. 2. Bi- and Tricyclic Derivatives Result in Superior Antiviral and Pharmacokinetic Profiles

Takashi Kawasuji, Brian A. Johns, Hiroshi Yoshida et al. · Journal of Medicinal Chemistry · 2013 · 89 citations

Antiviral Compound, Medicine, Immunology +14

Carbamoyl Pyridone HIV-1 Integrase Inhibitors. 1. Molecular Design and Establishment of an Advanced Two-Metal Binding Pharmacophore

Takashi Kawasuji, Brian A. Johns, Hiroshi Yoshida et al. · Journal of Medicinal Chemistry · 2012 · 56 citations · Full text

Pk Booster, Pharmacotherapy, Antiviral Drug +22

Proteolytic processing of amyloid β protein precursor (APP) by thrombin

Kenji Igarashi, Hitoshi Murai, J Asaka · Biochemical and Biophysical Research Communications · 1992 · 52 citations

Biochemistry, Protein Folding, Proteolytic Processing +5