Identification of existing pharmaceuticals and herbal medicines as inhibitors of SARS-CoV-2 infection

Jia-Tsrong Jan, Ting-Jen Rachel Cheng, Yu-Pu Juang, +14

Proceedings of the National Academy of Sciences

Discovery of Vaniprevir (MK-7009), a Macrocyclic Hepatitis C Virus NS3/4a Protease Inhibitor

John A. McCauley, Charles McIntyre, Michael T. Rudd, +19

Journal of Medicinal Chemistry

ImmunologyAntiviral DrugMedicinal ChemistryViral HepatitisAntiviral Drug Development +15

Molecular Modeling Based Approach to Potent P2−P4 Macrocyclic Inhibitors of Hepatitis C NS3/4A Protease

Nigel J. Liverton, M. Katharine Holloway, John A. McCauley, +14

Journal of the American Chemical Society

Molecular DockingMedicinal ChemistryInitial CompoundsAntiviral CompoundBiochemistry +12

Characterization of Plasmin-mediated Activation of Plasma Procarboxypeptidase B

Shi‐Shan Mao, Carolyn M. Cooper, Theresa Wood, +2

Journal of Biological Chemistry

Discovery of a Novel, Selective, and Orally Bioavailable Class of Thrombin Inhibitors Incorporating Aminopyridyl Moieties at the P1 Position

Dong-Mei Feng, Stephen J. Gardell, Sidney D. Lewis, +17

Journal of Medicinal Chemistry

Imidazole acetic acid TAFIa inhibitors: SAR studies centered around the basic P 1 ′ group

Philippe G. Nantermet, James C. Barrow, Stacey R. Lindsley, +9

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyMedicinal ChemistryBasic P 1Inhibitory ActivityBiochemistry +12

Synthesis and Evaluation of Imidazole Acetic Acid Inhibitors of Activated Thrombin-Activatable Fibrinolysis Inhibitor as Novel Antithrombotics

James C. Barrow, Philippe G. Nantermet, Shaun R. Stauffer, +16

Journal of Medicinal Chemistry

PharmacotherapyNovel AntithromboticsThrombosisMedicinal ChemistryHematology +15

Demonstration of enhanced endogenous fibrinolysis in thrombin activatable fibrinolysis inhibitor-deficient mice

Shi‐Shan Mao, Marie A. Holahan, Carolyn Bailey, +4

Blood Coagulation & Fibrinolysis

InflammationThrombosisThrombopoiesisSignal TransductionAdded Thrombin +13

Inhibition of Thrombin by Peptides Containing Lysyl-α-Keto Carbonyl Derivatives

S.D. Lewis, Assunta S. Ng, Elizabeth A. Lyle, +12

Thrombosis and Haemostasis

Thrombin InhibitorsPeptide SciencePharmacotherapyThrombosisMedicinal Chemistry +14

A time-resolved, internally quenched fluorescence assay to characterize inhibition of hepatitis C virus nonstructural protein 3–4A protease at low enzyme concentrations

Shi‐Shan Mao, Jillian DiMuzio, Carolyn McHale, +3

Analytical Biochemistry

Protein ChemistryVirus StructureBiochemistryFluorescence AssayViral Hepatitis +8