Antonı́n Holý

Differential antiherpesvirus and antiretrovirus effects of the (S) and (R) enantiomers of acyclic nucleoside phosphonates: potent and selective in vitro and in vivo antiretrovirus activities of (R)-9-(2-phosphonomethoxypropyl)-2,6-diaminopurine

Jan Balzarini, Antonı́n Holý, Jindřich Jindřich et al. · Antimicrobial Agents and Chemotherapy · 1993 · 343 citations

Bioorganic Chemistry, Biochemistry, Vivo Antiretrovirus Activities +15

Phosphonylmethoxyethyl purine derivatives, a new class of anti-human immunodeficiency virus agents

Rudi Pauwels, Jan Balzarini, Dominique Schols et al. · Antimicrobial Agents and Chemotherapy · 1988 · 256 citations · Full text

Medicinal Chemistry, Biochemistry, Medicine +15

(S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine, a potent and selective inhibitor of human cytomegalovirus replication

Robert Snoeck, Takashi Sakuma, Erik De Clercq et al. · Antimicrobial Agents and Chemotherapy · 1988 · 221 citations · Full text

Human Cytomegalovirus Replication, Medicinal Chemistry, Viral Replication +15

Marked in vivo antiretrovirus activity of 9-(2-phosphonylmethoxyethyl)adenine, a selective anti-human immunodeficiency virus agent.

Jan Balzarini, Lieve Naesens, Piet Herdewijn et al. · Proceedings of the National Academy of Sciences · 1989 · 217 citations · Full text

Human Immunodeficiency Virus, Vivo Antiretrovirus Activity, Medicine +15

Acyclic nucleotide analogues: Synthesis, antiviral activity and inhibitory effects on some cellular and virus-encoded enzymes in vitro

Antonı́n Holý, Ivan Votruba, Aleš Merta et al. · Antiviral Research · 1990 · 147 citations

Inhibitory Effects, Biochemistry, Virus-encoded Enzymes +10