Targeting acute ischemic stroke with a calcium-sensitive opener of maxi-K potassium channels

Valentin K. Gribkoff, John E. Starrett, Steven I. Dworetzky, +27

Nature Medicine

Cerebrovascular DiseaseSocial SciencesCerebral Vascular RegulationThrombosisHyperpolarization (Biology) +14

Quinazolinone Derivatives as Orally Available Ghrelin Receptor Antagonists for the Treatment of Diabetes and Obesity

Joachim Rudolph, William P. Esler, Stephen O’Connor, +29

Journal of Medicinal Chemistry

Food IntakePharmacotherapyType 1AInsulin SignalingGastrointestinal Peptide Hormone +15

A Novel Long-Acting Selective Neuropeptide Y2 Receptor Polyethylene Glycol-Conjugated Peptide Agonist Reduces Food Intake and Body Weight and Improves Glucose Metabolism in Rodents

Astrid Ortiz, Lucinda F. Milardo, Lynn B. DeCarr, +6

Journal of Pharmacology and Experimental Therapeutics

3-[(5-Chloro-2-hydroxyphenyl)methyl]-5-[4-(trifluoromethyl)phenyl ]-1,3,4-oxadiazol-2(3<i>H</i>)-one, BMS-191011:  Opener of Large-Conductance Ca²⁺-Activated Potassium (Maxi-K) Channels, Identification, Solubility, and SAR

J. Romine, Scott Martin, Nicholas A. Meanwell, +10

Journal of Medicinal Chemistry

Organic ChemistryBiomedical EngineeringChemistryCerebral Vascular RegulationMedicinal Chemistry +18

Dual-acting peptide with prolonged glucagon-like peptide-1 receptor agonist and glucagon receptor antagonist activity for the treatment of type 2 diabetes

Thomas H. Claus, Clark Q. Pan, Joanne Buxton, +9

Journal of Endocrinology

Metabolic SyndromeGlucose ToleranceGastrointestinal Peptide HormoneDiabetes ManagementBiochemistry +13

Temporal changes in superoxide dismutase, glutathione peroxidase, and catalase levels in primary and peri-ischemic tissue

Sahebarao P. Mahadik, Tapas K. Makar, Jayasimha N. Murthy, +3

Molecular and Chemical Neuropathology

BiochemistryRedox RegulatorTemporal ChangesLipid PeroxidationPhysiology +7

Pharmacological characterization and appetite suppressive properties of BMS-193885, a novel and selective neuropeptide Y1 receptor antagonist

Ildiko Antal‐Zimanyi, Marc A. Bruce, Karen L. LeBoulluec, +9

European Journal of Pharmacology

Molecular PharmacologyNeuropeptidesPharmacological CharacterizationAppetite Suppressive PropertiesAppetite Control +8

Novel Selective Neuropeptide Y2 Receptor PEGylated Peptide Agonists Reduce Food Intake and Body Weight in Mice

Kevin J. Lumb, Lynn B. DeCarr, Lucinda F. Milardo, +6

Journal of Medicinal Chemistry

NutritionFood IntakeGastrointestinal Peptide HormoneObesityMetabolic Syndrome +16

A long-acting selective neuropeptide Y2 receptor PEGylated peptide agonist reduces food intake in mice

Lynn B. DeCarr, Thomas M. Buckholz, Lucinda F. Milardo, +3

Bioorganic & Medicinal Chemistry Letters

NutritionMolecular PharmacologyGastrointestinal Peptide HormoneNeuropeptidesMedicine +6

Constrained analogs of CB-1 antagonists: 1,5,6,7-Tetrahydro-4H-pyrrolo[3,2-c]pyridine-4-one derivatives

Roger A. Smith, Zahra Fathi, Su-Ellen Brown, +15

Bioorganic & Medicinal Chemistry Letters

Cb-1 AntagonistsMedicinal ChemistryMedicinePharmacotherapyHeterocycle Chemistry +3