PA-824 Kills Nonreplicating <i>Mycobacterium tuberculosis</i> by Intracellular NO Release

Ramandeep Singh, Ujjini H. Manjunatha, Helena I. Boshoff, +11

Science

Bioorganic ChemistryNitric OxideTuberculosis PreventionInnate Immune SystemDrug Resistance +17

Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis

Kévin Pethe, Pablo Bifani, Jichan Jang, +51

Nature Medicine

Medicinal ChemistryPotent Clinical CandidatePulmonary TuberculosisMedicineImmunology +5

High Content Screening Identifies Decaprenyl-Phosphoribose 2′ Epimerase as a Target for Intracellular Antimycobacterial Inhibitors

Thierry Christophe, Mary Jackson, Hee Kyoung Jeon, +25

PLoS Pathogens

Antimicrobial ChemotherapyDrug ResistanceMedicinal ChemistryM. TuberculosisMycobacterium Tuberculosis +19

Lead Optimization of a Novel Series of Imidazo[1,2-<i>a</i>]pyridine Amides Leading to a Clinical Candidate (Q203) as a Multi- and Extensively-Drug-Resistant Anti-tuberculosis Agent

Sun‐Hee Kang, Ryang Yeo Kim, Min Jung Seo, +17

Journal of Medicinal Chemistry

Pharmaceutical ScienceBioorganic ChemistryExtensively-drug-resistant Anti-tuberculosis AgentClinical CandidatePharmacotherapy +16

Structure−Activity Relationships of Antitubercular Nitroimidazoles. 2. Determinants of Aerobic Activity and Quantitative Structure−Activity Relationships

Pilho Kim, Sun‐Hee Kang, Helena I. Boshoff, +11

Journal of Medicinal Chemistry

Medicinal ChemistryBioorganic ChemistryBiochemistryAntitubercular NitroimidazolesNatural Sciences +13

Design and synthesis of novel antimicrobial peptides on the basis of α helical domain of Tenecin 1, an insect defensin protein, and structure–activity relationship study

Hyesun Ahn, Cho Won-Mi, Sun‐Hee Kang, +4

Peptides

Antimicrobial Drug DiscoveryBiochemistryNatural SciencesPeptide EngineeringTenecin 1 +11

Synthesis and structure-activity studies of side chain analogues of the anti-tubercular agent, Q203

Sun‐Hee Kang, Young Mi Kim, Ryang Yeo Kim, +5

European Journal of Medicinal Chemistry

BiochemistryMedicineStructure-activity StudiesSide Chain AnaloguesAnti-tubercular Agent +4

Gadolinium Complex of DO3A-benzothiazole Aniline (BTA) Conjugate as a Theranostic Agent

Hee-Kyung Kim, Minkyoung Kang, Ki‐Hye Jung, +6

Journal of Medicinal Chemistry

EngineeringMr ImagesOrganic ChemistryTheranostic AgentChemistry +16

Aquaporin 3 Expression Predicts Survival in Patients with HER2-positive Early Breast Cancer.

Sun‐Hee Kang, Yee Soo Chae, Soo Jung Lee, +8

PubMed

Synthesis and structure-activity relationships of novel fused ring analogues of Q203 as antitubercular agents

Sun‐Hee Kang, Young Mi Kim, Hee-Kyung Jeon, +9

European Journal of Medicinal Chemistry

Medicinal ChemistryHeterocyclicNatural SciencesMedicineAntitubercular Agents +5