Phillip P. Knowles

Structure and Chemical Inhibition of the RET Tyrosine Kinase Domain

Phillip P. Knowles, Judith Murray‐Rust, Rizaldy P. Scott et al. · Journal of Biological Chemistry · 2006 · 306 citations · Full text

Medicine, Biochemistry, Molecular Biology +17

New coupling agents for the synthesis of immunotoxins containing a hindered disulfide bond with improved stability in vivo.

Philip E. Thorpe, Philip M. Wallace, Phillip P. Knowles et al. · PubMed · 1987 · 204 citations

Life Sciences, Immunology, Pharmacology +12

Effect of chemical deglycosylation of ricin A chain on the in vivo fate and cytotoxic activity of an immunotoxin composed of ricin A chain and anti-Thy 1.1 antibody.

David C. Blakey, Graham J. Watson, Phillip P. Knowles et al. · PubMed · 1987 · 132 citations

Life Sciences, Biochemistry, Immunology +9

A secondary RET mutation in the activation loop conferring resistance to vandetanib

Takashi Nakaoku, Takashi Kohno, Mitsugu Araki et al. · Nature Communications · 2018 · 106 citations · Full text

Medicine, Molecular Biology, Oncology +15

Structure of a Conserved Dimerization Domain within the F-box Protein Fbxo7 and the PI31 Proteasome Inhibitor

Rebecca Kirk, Heike Laman, Phillip P. Knowles et al. · Journal of Biological Chemistry · 2008 · 94 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17