Mitsugu Araki

Brigatinib combined with anti-EGFR antibody overcomes osimertinib resistance in EGFR-mutated non-small-cell lung cancer

Ken Uchibori, Naohiko Inase, Mitsugu Araki et al. · Nature Communications · 2017 · 402 citations · Full text

<i>In silico</i> discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras–effector interaction

Fumi Shima, Yoko Yoshikawa, Min Ye et al. · Proceedings of the National Academy of Sciences · 2013 · 292 citations · Full text

Structural Basis for Conformational Dynamics of GTP-bound Ras Protein

Fumi Shima, Yuichi Ijiri, Shin Muraoka et al. · Journal of Biological Chemistry · 2010 · 150 citations · Full text

X-ray Crystallography, Conformational Dynamics, State Transition +14

Landscape and function of multiple mutations within individual oncogenes

Yuki Saito, Junji Koya, Mitsugu Araki et al. · Nature · 2020 · 146 citations

Allelic Variant, Somatic Variant, Multiple Mutations +5

Prediction of ALK mutations mediating ALK-TKIs resistance and drug re-purposing to overcome the resistance

Koutaroh Okada, Mitsugu Araki, Takuya Sakashita et al. · EBioMedicine · 2019 · 125 citations · Full text