Yuichi Ijiri

<i>In silico</i> discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras–effector interaction

Fumi Shima, Yoko Yoshikawa, Min Ye et al. · Proceedings of the National Academy of Sciences · 2013 · 292 citations · Full text

Structural Basis for Conformational Dynamics of GTP-bound Ras Protein

Fumi Shima, Yuichi Ijiri, Shin Muraoka et al. · Journal of Biological Chemistry · 2010 · 150 citations · Full text

X-ray Crystallography, Conformational Dynamics, State Transition +14

Solution Structure of the State 1 Conformer of GTP-bound H-Ras Protein and Distinct Dynamic Properties between the State 1 and State 2 Conformers

Mitsugu Araki, Fumi Shima, Yoko Yoshikawa et al. · Journal of Biological Chemistry · 2011 · 108 citations · Full text

Conformational Dynamics, Molecular Biology, Molecular Dynamics +16

Crystal structures of the state 1 conformations of the GTP‐bound H‐Ras protein and its oncogenic G12V and Q61L mutants

Shin Muraoka, Fumi Shima, Mitsugu Araki et al. · FEBS Letters · 2012 · 87 citations

Critical Roles of Interactions among Switch I-preceding Residues and between Switch II and Its Neighboring α-Helix in Conformational Dynamics of the GTP-bound Ras Family Small GTPases

Kousuke Matsumoto, Fumi Shima, Shin Muraoka et al. · Journal of Biological Chemistry · 2011 · 16 citations · Full text