Small-molecule p21-activated kinase inhibitor PF-3758309 is a potent inhibitor of oncogenic signaling and tumor growth

Brion W. Murray, Chuangxing Guo, Joseph Piraino, +16

Proceedings of the National Academy of Sciences

Interphylal Product Splicing:  The First Total Syntheses of Cephalostatin 1, the North Hemisphere of Ritterazine G, and the Highly Active Hybrid Analogue, Ritterostatin G_N1_N¹

Thomas Lacour, Chuangxing Guo, Sudhakar Bhandaru, +2

Journal of the American Chemical Society

Bioorganic ChemistryMolecular BiologyConvergent Total SynthesesChemical BiologyPharmaceutical Chemistry +19

Structure-based design of novel human Pin1 inhibitors (I)

Chuangxing Guo, Xinjun Hou, Liming Dong, +15

Bioorganic & Medicinal Chemistry Letters

Molecular DockingDrug TargetMedicineRational Drug DesignStructure-based Design +2

Structure-based design of novel human Pin1 inhibitors (II)

Liming Dong, Joseph Marakovits, Xinjun Hou, +9

Bioorganic & Medicinal Chemistry Letters

Molecular DockingDrug TargetMedicineRational Drug DesignStructure-based Design +2

Systematic Structure Modifications of Imidazo[1,2-<i>a</i>]pyrimidine to Reduce Metabolism Mediated by Aldehyde Oxidase (AO)

Angelica Linton, Ping Kang, Martha A. Ornelas, +5

Journal of Medicinal Chemistry

Androgen ReceptorBioorganic ChemistryMolecular BiologyPharmacotherapyChemical Biology +20

The first synthesis of the aglycone of the potent anti-tumor steroidal saponin OSW-1

Chuangxing Guo, P. L. Fuchs

Tetrahedron Letters

First SynthesisMedicinal ChemistryBiochemistryNatural SciencesMedicine +2

Discovery of Aryloxy Tetramethylcyclobutanes as Novel Androgen Receptor Antagonists

Chuangxing Guo, Angelica Linton, Susan E. Kephart, +26

Journal of Medicinal Chemistry

On the relationship of OSW-1 to the cephalostatins

Chuangxing Guo, Thomas Lacour, P. L. Fuchs

Bioorganic & Medicinal Chemistry Letters

Bioorganic ChemistryBiochemistryNatural SciencesGlycobiologyMolecular Biology +4

Synthesis, Properties, Oxidation, and Electrochemistry of 1,2-Dichalcogenins

Eric Block, Marc Birringer, Russell J. DeOrazio, +11

Journal of the American Chemical Society

Transition Metal ChalcogenidesEngineering1,2-Dithiin Radical CationHeterocyclicAlkene Metathesis +9

Discovery of Pyrroloaminopyrazoles as Novel PAK Inhibitors

Chuangxing Guo, Indrawan McAlpine, Junhu Zhang, +22

Journal of Medicinal Chemistry

Medicinal ChemistryPharmaceutical ChemistryBiochemistryMedicineTumor Growth +13