Interleukin 6 reduces lipoprotein lipase activity in adipose tissue of mice in vivo and in 3T3-L1 adipocytes: a possible role for interleukin 6 in cancer cachexia.

Andrew S. Greenberg, Richard P. Nordan, Joe McIntosh, +3

PubMed

Fat ReservesImmunologyPathologyMetabolic RemodelingInflammation +16

Antitumor activity of recombinant interleukin 6 in mice.

James J. Mulé, Joe McIntosh, David M. Jablons, +1

The Journal of Experimental Medicine

Il-6 InjectionsPurified Human Ril-6Antitumor ActivityImmunologyPathology +15

IL-6/IFN-<i>beta</i>-2 as a circulating hormone. Induction by cytokine administration in humans.

David M. Jablons, James J. Mulé, Joe McIntosh, +5

The Journal of Immunology

An Anti-Wnt-2 Monoclonal Antibody Induces Apoptosis in Malignant Melanoma Cells and Inhibits Tumor Growth

Liang You, Biao He, Zhidong Xu, +9

Cancer Research

Chemoprevention StrategyApoptosisImmunologyCell DeathImmunotherapy +15

A randomized trial of avatrombopag, an investigational thrombopoietin-receptor agonist, in persistent and chronic immune thrombocytopenia

James B. Bussel, David J. Kuter, Louis M. Aledort, +5

Blood

Synergistic antitumor effects of combination immunotherapy with recombinant interleukin-2 and a recombinant hybrid alpha-interferon in the treatment of established murine hepatic metastases.

R B Cameron, Joe McIntosh, S A Rosenberg

PubMed

ImmunologyPathologyImmunotherapyCombination ImmunotherapyOncology +15

In vivo induction of IL-6 by administration of exogenous cytokines and detection of de novo serum levels of IL-6 in tumor-bearing mice.

Joe McIntosh, David M. Jablons, James J. Mulé, +4

The Journal of Immunology

ImmunologyImmunologic MechanismVivo InductionSerum Il-6Immune Dysregulation +14

Synergistic antitumor effects of immunotherapy with recombinant interleukin-2 and recombinant tumor necrosis factor-alpha.

Joe McIntosh, James J. Mulé, Maria J. Merino, +1

PubMed

ImmunologyImmunoeditingPathologyMetronomic ChemotherapyImmunotherapy +18

Phase II study of avatrombopag in thrombocytopenic patients with cirrhosis undergoing an elective procedure

Norah A. Terrault, Tarek Hassanein, Charles D. Howell, +7

Journal of Hepatology

Thrombocytopenic PatientsThrombosisThrombopoiesisVenous ThrombosisHepatology +11

Augmentation of antitumor efficacy by the combination of recombinant tumor necrosis factor and chemotherapeutic agents in vivo.

Jody A. Krosnick, James J. Mulé, Joe McIntosh, +1

PubMed

ImmunologyAntitumor EfficacyImmunotherapeuticsPharmacotherapyMetronomic Chemotherapy +14