The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress

Atsuko Nakai, Osamu Yamaguchi, Toshihiro Takeda, +11

Nature Medicine

MechanobiologyCardiac MuscleMitophagyHeart FailureBasal State +11

Inhibition of autophagy in the heart induces age-related cardiomyopathy

Manabu Taneike, Osamu Yamaguchi, Atsuko Nakai, +14

Autophagy

p38α Mitogen-Activated Protein Kinase Plays a Critical Role in Cardiomyocyte Survival but Not in Cardiac Hypertrophic Growth in Response to Pressure Overload

Kazuhiko Nishida, Osamu Yamaguchi, Shinichi Hirotani, +21

Molecular and Cellular Biology

Cardiac MuscleHeart FailureCardiomyocyte SurvivalCell DeathCardiovascular Function +17

Cardiac-specific disruption of the c-raf-1 gene induces cardiac dysfunction and apoptosis

Osamu Yamaguchi, Tetsuya Watanabe, Kazuhiko Nishida, +18

Journal of Clinical Investigation

Cardiac-specific disruption of the c-raf-1 gene induces cardiac dysfunction and apoptosis

Osamu Yamaguchi, Tetsuya Watanabe, Kazuhiko Nishida, +18

Journal of Clinical Investigation

The Antioxidant Edaravone Attenuates Pressure Overload–Induced Left Ventricular Hypertrophy

Ikuko Tsujimoto, Shungo Hikoso, Osamu Yamaguchi, +10

Hypertension

Cardiovascular ToxicityHypertensionHeart FailureCardiovascular DiseaseMedicine +13

CaMKII activates ASK1 and NF-κB to induce cardiomyocyte hypertrophy

Kazunori Kashiwase, Yoshiharu Higuchi, Shinichi Hirotani, +12

Biochemical and Biophysical Research Communications

Cardiac MuscleCardiomyopathyMolecular PhysiologySignal TransductionPhysiology +6

Apoptosis Signal-Regulating Kinase 1/p38 Signaling Pathway Negatively Regulates Physiological Hypertrophy

Masayuki Taniike, Osamu Yamaguchi, Ikuko Tsujimoto, +12

Circulation

Apoptosis signal-regulating kinase 1 is involved not only in apoptosis but also in non-apoptotic cardiomyocyte death

Tetsuya Watanabe, Kinya Otsu, Toshihiro Takeda, +10

Biochemical and Biophysical Research Communications

Cardiac MuscleCardiomyopathyHeart FailureSignal TransductionReceptor Tyrosine Kinase +8

Presenilin 2 regulates the systolic function of heart by modulating Ca ²⁺ signaling

Toshihiro Takeda, Michio Asahi, Osamu Yamaguchi, +18

The FASEB Journal