Deidre Madsen

Conformationally-restricted analogues of efflux pump inhibitors that potentiate the activity of levofloxacin in Pseudomonas aeruginosa

Thomas E. Renau, Roger Léger, L. K. FILONOVA et al. · Bioorganic & Medicinal Chemistry Letters · 2003 · 95 citations

Efflux Pump Inhibitors, Antimicrobial Susceptibility, Antibiotics +11

The relationship between physicochemical properties, In vitro activity and pharmacokinetic profiles of analogues of diamine-Containing efflux pump inhibitors

William J. Watkins, Yakira Landaverry, Roger Léger et al. · Bioorganic & Medicinal Chemistry Letters · 2003 · 79 citations

Medicinal Chemistry, Pharmaceutical Science, Biochemistry +9

Quinazolinone fungal efflux pump inhibitors. Part 3: (N-methyl)piperazine variants and pharmacokinetic optimization

William J. Watkins, Lee S. Chong, Aesop Cho et al. · Bioorganic & Medicinal Chemistry Letters · 2007 · 24 citations

Antifungal Agent, Medicine, Pharmacokinetic Optimization +7

Quinazolinone-based fungal efflux pump inhibitors. Part 1: Discovery of an (N-methylpiperazine)-containing derivative with activity in clinically relevant Candida spp.

Rémy C. Lemoine, Tomasz Glinka, William J. Watkins et al. · Bioorganic & Medicinal Chemistry Letters · 2004 · 21 citations

Medicinal Chemistry, Antifungal Agent, Medicine +6

Quinazolinone fungal efflux pump inhibitors. Part 2: In vitro structure–activity relationships of (N-methyl-piperazinyl)-containing derivatives

William J. Watkins, Rémy C. Lemoine, Lee S. Chong et al. · Bioorganic & Medicinal Chemistry Letters · 2004 · 17 citations

Molecular Pharmacology, Medicinal Chemistry, Pharmaceutical Chemistry +10