Concepedia

Quinazolinone fungal efflux pump inhibitors. Part 2: In vitro structure–activity relationships of (N-methyl-piperazinyl)-containing derivatives

William J. Watkins, Rémy C. Lemoine, Lee S. Chong, Aesop Cho, Thomas E. Renau, Bonnie Kuo, Vickie Wong, M. LUDWIKOW, Negar Garizi, Nadeem Iqbal,

Bioorganic & Medicinal Chemistry Letters · 2004 · 18 citations · 2 references

Concepts

PharmacyMedicinal ChemistryPharmacologyDrug DesignDrug DiscoveryStructure-activity RelationshipsAntifungal AgentsAntifungal PharmacologyAntifungal ResistanceCellular Drug EffluxEnzyme InhibitionStructure-activity Relationship AnalysisChemical Structure-activity RelationshipsDrug Efflux PumpsEfflux Inhibitor DevelopmentFungal Enzyme InhibitorsSmall-molecule Efflux Inhibitors

References

2

Atropisomeric Amides as Chiral Ligands: Using (−)-Sparteine-Directed Enantioselective Silylation to Control the Conformation of a Stereogenic Axis

Jonathan Clayden, Paul D. Johnson, Jennifer H. Pink et al. · The Journal of Organic Chemistry · 2000 · 138 citations

Natural Sciences, Chemistry, Catalysis +13

Quinazolinone-based fungal efflux pump inhibitors. Part 1: Discovery of an (N-methylpiperazine)-containing derivative with activity in clinically relevant Candida spp.

Rémy C. Lemoine, Tomasz Glinka, William J. Watkins et al. · Bioorganic & Medicinal Chemistry Letters · 2004 · 22 citations

Life Sciences, Medicinal Chemistry, Microbiology +14