Utilization of the 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold in the design of potent inhibitors of serine proteases: SAR studies using carboxylates

Rongze Kuang, Jeffrey B. Epp, Sumei Ruan, +6

Bioorganic & Medicinal Chemistry

Combinatorial ChemistryMedicinal Chemistry1,2,5-Thiadiazolidin-3-one 1,1BiochemistryMedicine +9

Asymmetric Synthesis of Calyculin C. 1. Synthesis of the C₁−C₂₅ Fragment

Gerard R. Scarlato, John A. DeMattei, Lee S. Chong, +3

The Journal of Organic Chemistry

Combinatorial ChemistryMedicinal ChemistrySerine/threonine Phosphatase Pp1Bioorganic ChemistryEngineering +13

Isoxazoline derivatives as potential inhibitors of the proteolytic enzymes human leukocyte elastase, cathepsin G and proteinase 3: a structure-activity relationship study

William C. Groutas, R. Venkataraman, Lee S. Chong, +4

Bioorganic & Medicinal Chemistry

Cellular EnzymologyBiochemistryCathepsin GNatural SciencesMedicine +11

Discovery of GS-9669, a Thumb Site II Non-Nucleoside Inhibitor of NS5B for the Treatment of Genotype 1 Chronic Hepatitis C Infection

Scott E. Lazerwith, Willard Lew, Jennifer Zhang, +24

Journal of Medicinal Chemistry

Drug TargetAntiviral DrugChemical BiologyPharmaceutical ChemistryClinical Candidate Gs-9669 +15

HCV NS5B polymerase inhibitors.

William J. Watkins, Adrian S. Ray, Lee S. Chong

PubMed

Medicinal ChemistryHcv Ns5b PolymeraseViral Polymerase StructureMedicineChemical Series +13

Asymmetric Synthesis of Calyculin C. 2. Synthesis of the C₂₆−C₃₇ Fragment and Model Wittig Couplings

Anthony K. Ogawa, John A. DeMattei, Gerard R. Scarlato, +3

The Journal of Organic Chemistry

Combinatorial ChemistryMedicinal ChemistryCross-coupling ReactionBioorganic ChemistryModel Wittig Couplings +13

Quinazolinone fungal efflux pump inhibitors. Part 3: (N-methyl)piperazine variants and pharmacokinetic optimization

William J. Watkins, Lee S. Chong, Aesop Cho, +16

Bioorganic & Medicinal Chemistry Letters

Antifungal AgentMedicinePharmacokinetic OptimizationPharmacotherapyMicrobiology +5

Amino Acid-Derived Phthalimide and Saccharin Derivatives as Inhibitors of Human Leukocyte Elastase, Cathepsin G, and Proteinase 3

William C. Groutas, Lee S. Chong, R. Venkataraman, +5

Archives of Biochemistry and Biophysics

BiochemistryMedicineNatural SciencesGlycobiologyPeptide Therapeutic +5

1,2,5-Thiadiazolidin-3-one 1,1 Dioxide: A Powerful Scaffold for Probing the S′ Subsites of (Chymo)trypsin-Like Serine Proteases

William C. Groutas, Jeffrey B. Epp, Rongze Kuang, +10

Archives of Biochemistry and Biophysics

Protein ChemistryProtein FunctionPowerful ScaffoldBiochemistryNatural Sciences +4

Phosphonic acid-containing analogues of mycophenolic acid as inhibitors of IMPDH

William J. Watkins, James Chen, Aesop Cho, +12

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryBiochemistryMycophenolic AcidMedicineNatural Sciences +4