Azepanone-Based Inhibitors of Human and Rat Cathepsin K

Robert W. Marquis, Yu Ru, Steven M. LoCastro, +36

Journal of Medicinal Chemistry

Discovery of a Novel 2,6-Disubstituted Glucosamine Series of Potent and Selective Hexokinase 2 Inhibitors

Lin Hong, Jin Zeng, Ren Xie, +27

ACS Medicinal Chemistry Letters

Cyclic Ketone Inhibitors of the Cysteine Protease Cathepsin K

Robert W. Marquis, Yu Ru, Jin Zeng, +16

Journal of Medicinal Chemistry

Medicinal ChemistryAldo-keto ReductaseBiochemistryNatural SciencesMedicine +11

Synthesis and structure–activity relationships of imidazo[1,2-a]pyrimidin-5(1H)-ones as a novel series of beta isoform selective phosphatidylinositol 3-kinase inhibitors

Hong Lin, Karl F. Erhard, Mary Ann Hardwicke, +14

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyMedicinal ChemistryNovel SeriesBiochemistryNatural Sciences +9

Rational Design, Synthesis, and SAR of a Novel Thiazolopyrimidinone Series of Selective PI3K-beta Inhibitors

Hong Lin, Mark J. Schulz, Ren Xie, +18

ACS Medicinal Chemistry Letters

Combinatorial ChemistryChemoprevention StrategyPharmacotherapyHeterocycle ChemistryPharmaceutical Chemistry +18

Azepanone-Based Inhibitors of Human Cathepsin L

Robert W. Marquis, Ian E. James, Jin Zeng, +15

Journal of Medicinal Chemistry

Medicinal ChemistryPharmaceutical ChemistryCathepsin LBiochemistryInhibitor Selectivity +13

Extracellular vesicles enhance oxidative stress through P38/NF‐kB pathway in ketamine‐induced ulcerative cystitis

Xiao Jian Xi, Jin Zeng, Yong Lu, +4

Journal of Cellular and Molecular Medicine

Extracellular MicrovesiclesCellular PharmacologyExperimental PharmacologyCellular PhysiologyOxidative Stress +16

2,3,5-Trisubstituted pyridines as selective AKT inhibitors—Part I: Substitution at 2-position of the core pyridine for ROCK1 selectivity

Hong Lin, Dennis S. Yamashita, Jin Zeng, +14

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyMedicinal ChemistryMedicineNatural SciencesOrganic Chemistry +7

Hydrogen-bonding network in heme active site regulates the hydrolysis activity of myoglobin

Jin Zeng, Yuan Zhao, Wei Li, +3

Journal of Molecular Catalysis B Enzymatic

Periodic Surface StructuresBiochemistryProtein FoldingNatural SciencesMolecular Biology +8

2,3,5-Trisubstituted pyridines as selective AKT inhibitors. Part II: Improved drug-like properties and kinase selectivity from azaindazoles

Hong Lin, Dennis S. Yamashita, Jin Zeng, +12

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryMedicineDrug DiscoveryRational Drug DesignPharmacological Agent +8