Concepedia

Synthesis and structure–activity relationships of imidazo[1,2-a]pyrimidin-5(1H)-ones as a novel series of beta isoform selective phosphatidylinositol 3-kinase inhibitors

Hong Lin, Karl F. Erhard, Mary Ann Hardwicke, Juan I. Luengo, James F. Mack, Jeanelle McSurdy-Freed, Ramona Plant, Kaushik Raha, Cynthia M. Rominger, Robert M. Sanchez,

Bioorganic & Medicinal Chemistry Letters · 2012 · 41 citations · 18 references

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18

A Pharmacological Map of the PI3-K Family Defines a Role for p110α in Insulin Signaling

Zachary A. Knight, Beatriz González, Morri E. Feldman et al. · Cell · 2006 · 1.2K citations · Full text

, , +14

Essential roles of PI(3)K–p110β in cell growth, metabolism and tumorigenesis

Shidong Jia, Zhenning Liu, Sen Zhang et al. · Nature · 2008 · 684 citations · Full text

, , +16

Analysis of <i>PTEN</i> , <i>BRAF</i> , and <i>EGFR</i> Status in Determining Benefit From Cetuximab Therapy in Wild-Type <i>KRAS</i> Metastatic Colon Cancer

Pierre Laurent‐Puig, Anne Cayre, Gilles Manceau et al. · Journal of Clinical Oncology · 2009 · 665 citations

, , +17

Aberrant ERG expression cooperates with loss of PTEN to promote cancer progression in the prostate

Brett S. Carver, Jennifer Tran, Anuradha Gopalan et al. · Nature Genetics · 2009 · 661 citations · Full text

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The Structure of a Human p110α/p85α Complex Elucidates the Effects of Oncogenic PI3Kα Mutations

Chuan‐Hsiang Huang, Diana Mandelker, Oleg Schmidt‐Kittler et al. · Science · 2007 · 561 citations

, , +15