Akihito Ohta

The CUL3–KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction

Akihito Ohta, Frances‐Rose Schumacher, Youcef Mehellou et al. · Biochemical Journal · 2013 · 219 citations · Full text

Hypertension Syndrome Interacts, Genetics, Immunology +16

Dietary salt regulates the phosphorylation of OSR1/SPAK kinases and the sodium chloride cotransporter through aldosterone

Motoko Chiga, Tatemitsu Rai, Sung‐Sen Yang et al. · Kidney International · 2008 · 194 citations · Full text

Signal Transduction, Molecular Physiology, Biochemistry +11

Targeted disruption of the Wnk4 gene decreases phosphorylation of Na-Cl cotransporter, increases Na excretion and lowers blood pressure

Akihito Ohta, Tatemitsu Rai, Naofumi Yui et al. · Human Molecular Genetics · 2009 · 106 citations · Full text

Acute Insulin Stimulation Induces Phosphorylation of the Na-Cl Cotransporter in Cultured Distal mpkDCT Cells and Mouse Kidney

Eisei Sohara, Tatemitsu Rai, Sung‐Sen Yang et al. · PLoS ONE · 2011 · 91 citations · Full text

Na-cl Cotransporter, Nacl Cotransporter, Mpkdct Cells +19

Phenotypes of pseudohypoaldosteronism type II caused by the WNK4 D561A missense mutation are dependent on the WNK-OSR1/SPAK kinase cascade

Motoko Chiga, Fatema H. Rafiqi, Dario R. Alessi et al. · Journal of Cell Science · 2011 · 69 citations