Motoko Chiga

Molecular Pathogenesis of Pseudohypoaldosteronism Type II: Generation and Analysis of a Wnk4 Knockin Mouse Model

Sung‐Sen Yang, Tetsuji Morimoto, Tatemitsu Rai et al. · Cell Metabolism · 2007 · 307 citations · Full text

Medicine, Molecular Genetics, Molecular Medicine +4

Impaired KLHL3-Mediated Ubiquitination of WNK4 Causes Human Hypertension

Mai Wakabayashi, Takayasu Mori, Kiyoshi Isobe et al. · Cell Reports · 2013 · 217 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +8

Dietary salt regulates the phosphorylation of OSR1/SPAK kinases and the sodium chloride cotransporter through aldosterone

Motoko Chiga, Tatemitsu Rai, Sung‐Sen Yang et al. · Kidney International · 2008 · 194 citations · Full text

Medicine, Endocrinology, Physiology +16

Targeted disruption of the Wnk4 gene decreases phosphorylation of Na-Cl cotransporter, increases Na excretion and lowers blood pressure

Akihito Ohta, Tatemitsu Rai, Naofumi Yui et al. · Human Molecular Genetics · 2009 · 107 citations · Full text

Life Sciences, Molecular Biology, Physiology +17

Phosphatidylinositol 3-Kinase/Akt Signaling Pathway Activates the WNK-OSR1/SPAK-NCC Phosphorylation Cascade in Hyperinsulinemic db/db Mice

Hidenori Nishida, Eisei Sohara, Naohiro Nomura et al. · Hypertension · 2012 · 106 citations · Full text

Medicine, Biochemistry, Endocrinology +17