Ira Pastan

A recombinant immunotoxin consisting of two antibody variable domains fused to Pseudomonas exotoxin

Vijay K. Chaudhary, Gary Queen, Richard P. Junghans et al. · Nature · 1989 · 418 citations

Microbial Toxin, Toxinology, Medicine +10

A method for increasing the yield of properly folded recombinant fusion proteins: Single-chain immunotoxins from renaturation of bacterial inclusion bodies

Johannes Büchner, Ira Pastan, Ulrich Brinkmann · Analytical Biochemistry · 1992 · 342 citations

Recombinant Fusion Proteins, Protein Folding, Natural Sciences +10

Selective killing of HIV-infected cells by recombinant human CD4-Pseudomonas exotoxin hybrid protein

Vijay K. Chaudhary, Tamio Mizukami, Thomas R. Fuerst et al. · Nature · 1988 · 254 citations

Selective Killing, Human Retrovirus, Hiv-infected Cells +5

Characterization of epidermal growth factor receptor gene expression in malignant and normal human cell lines.

Y H Xu, Nancy Richert, Seiji Ito et al. · Proceedings of the National Academy of Sciences · 1984 · 230 citations · Full text

Cancer Research, Signal Transduction, Cancer Cell Biology +14

B3(Fv)-PE38KDEL, a single-chain immunotoxin that causes complete regression of a human carcinoma in mice.

Ulrich Brinkmann, Lee H. Pai, D J FitzGerald et al. · Proceedings of the National Academy of Sciences · 1991 · 217 citations · Full text

Immunotoxicology, Immunology, Pathology +23