A recombinant immunotoxin consisting of two antibody variable domains fused to Pseudomonas exotoxin

Vijay K. Chaudhary, Gary Queen, Richard P. Junghans, +3

Nature

Microbial ToxinToxinologyMedicineVirulence FactorPathogenesis +8

A method for increasing the yield of properly folded recombinant fusion proteins: Single-chain immunotoxins from renaturation of bacterial inclusion bodies

Johannes Büchner, Ira Pastan, Ulrich Brinkmann

Analytical Biochemistry

Recombinant Fusion ProteinsProtein FoldingNatural SciencesImmunologyMolecular Biology +8

Selective killing of HIV-infected cells by recombinant human CD4-Pseudomonas exotoxin hybrid protein

Vijay K. Chaudhary, Tamio Mizukami, Thomas R. Fuerst, +4

Nature

Selective KillingHuman RetrovirusHiv-infected CellsImmunologyAntiviral Response +3

Characterization of epidermal growth factor receptor gene expression in malignant and normal human cell lines.

Y H Xu, Nancy Richert, Seiji Ito, +2

Proceedings of the National Academy of Sciences

Cancer ResearchSignal TransductionCancer Cell BiologyPathologyCell Lines +12

B3(Fv)-PE38KDEL, a single-chain immunotoxin that causes complete regression of a human carcinoma in mice.

Ulrich Brinkmann, Lee H. Pai, D J FitzGerald, +2

Proceedings of the National Academy of Sciences

ImmunotoxicologyImmunologyPathologyEscherichia ColiImmunologic Mechanism +21

Phorbol esters induce transient internalization without degradation of unoccupied epidermal growth factor receptors.

Laura Beguinot, John A. Hanover, Seiji Ito, +3

Proceedings of the National Academy of Sciences

Pma-induced InternalizationHuman GrowthImmunologyCell GrowthCellular Physiology +17

MDR1 Gene Expression in Lung Cancer

Shih-Wei Lai, Lori J. Goldstein, M M Gottesman, +7

JNCI Journal of the National Cancer Institute

Mdr1 RnaOncologyMedicinePathologyBronchial Neoplasm +10

Activity of a recombinant fusion protein between transforming growth factor type alpha and Pseudomonas toxin.

Vijay K. Chaudhary, D J FitzGerald, Sankar Adhya, +1

Proceedings of the National Academy of Sciences

ToxinologyImmunologyMolecular BiologyPathologyEscherichia Coli +15

Expression of the interleukin 6 receptor and interleukin 6 in prostate carcinoma cells.

Clay B. Siegall, G Schwab, Richard P. Nordan, +2

PubMed

Cancer ResearchCytokineUrologyProstatic Carcinoma CellsMedicine +11

Activity of immunotoxins constructed with modified Pseudomonas exotoxin A lacking the cell recognition domain.

Tomomi Kondo, D J FitzGerald, Vijay K. Chaudhary, +2

Journal of Biological Chemistry

Microbial ToxinToxinologyBiochemistryVirulence FactorPathogenesis +10