Jean‐Pierre Hachem

pH Directly Regulates Epidermal Permeability Barrier Homeostasis, and Stratum Corneum Integrity/Cohesion

Jean‐Pierre Hachem, Debra Crumrine, Joachim W. Fluhr et al. · Journal of Investigative Dermatology · 2003 · 526 citations · Full text

Life Sciences, Dermatology, Cell Adhesion +14

Short-Term Glucocorticoid Treatment Compromises Both Permeability Barrier Homeostasis and Stratum Corneum Integrity: Inhibition of Epidermal Lipid Synthesis Accounts for Functional Abnormalities

Jack Kao, Joachim W. Fluhr, Mao‐Qiang Man et al. · Journal of Investigative Dermatology · 2003 · 361 citations

Life Sciences, Biochemistry, Dermatology +15

Sustained Serine Proteases Activity by Prolonged Increase in pH Leads to Degradation of Lipid Processing Enzymes and Profound Alterations of Barrier Function and Stratum Corneum Integrity

Jean‐Pierre Hachem, Debra Crumrine, Yoshikazu Uchida et al. · Journal of Investigative Dermatology · 2005 · 313 citations · Full text

Life Sciences, Biochemistry, Dermatology +17

Caspase-14 protects against epidermal UVB photodamage and water loss

Geertrui Denecker, Esther Hoste, Barbara Gilbert et al. · Nature Cell Biology · 2007 · 294 citations

Life Sciences, Cell Biology, Dermatology +16

Filaggrin Genotype in Ichthyosis Vulgaris Predicts Abnormalities in Epidermal Structure and Function

Robert Gruber, Peter M. Elias, Debra Crumrine et al. · American Journal Of Pathology · 2011 · 239 citations · Full text

Life Sciences, Genetics, Molecular Genetics +11