Fueling Open‐Source Drug Discovery: 177 Small‐Molecule Leads against Tuberculosis

Lluís Ballell, Robert H. Bates, Rob J. Young, +21

ChemMedChem

Identification of Novel Imidazo[1,2-a]pyridine Inhibitors Targeting M. tuberculosis QcrB

Katherine A. Abrahams, Jonathan A. G. Cox, Vickey L. Spivey, +9

PLoS ONE

Discovery of a Potent and Specific <i>M. tuberculosis</i> Leucyl-tRNA Synthetase Inhibitor: (<i>S</i>)-3-(Aminomethyl)-4-chloro-7-(2-hydroxyethoxy)benzo[<i>c</i>][1,2]oxaborol-1(3<i>H</i>)-ol (GSK656)

Xianfeng Li, Vincent Hernandez, Fernando Rock, +18

Journal of Medicinal Chemistry

Identification and Activity of a Series of Azole-based Compounds with Lactate Dehydrogenase-directed Anti-malarial Activity

Angus Cameron, Jon Read, R. Tranter, +19

Journal of Biological Chemistry

Tetrahydropyrazolo[1,5-a]Pyrimidine-3-Carboxamide and N-Benzyl-6′,7′-Dihydrospiro[Piperidine-4,4′-Thieno[3,2-c]Pyran] Analogues with Bactericidal Efficacy against Mycobacterium tuberculosis Targeting MmpL3

Modesto J. Remuiñán, Esther Pérez‐Herrán, Joaquín Rullás, +24

PLoS ONE

Tuberculosis PreventionLead SeriesAntimicrobial ChemotherapySpiro SeriesDrug Resistance +17

Discovery of Novel Oral Protein Synthesis Inhibitors of Mycobacterium tuberculosis That Target Leucyl-tRNA Synthetase

Andrés Palencia, Xianfeng Li, Wei Bu, +34

Antimicrobial Agents and Chemotherapy

Drug TargetMolecular BiologyAntimicrobial ChemotherapyProtein SynthesisDrug Resistance +16

Rapid Cytolysis of Mycobacterium tuberculosis by Faropenem, an Orally Bioavailable β-Lactam Antibiotic

Neeraj Dhar, Vincent Dubée, Lluís Ballell, +6

Antimicrobial Agents and Chemotherapy

Identification of KasA as the cellular target of an anti-tubercular scaffold

Katherine A. Abrahams, Chun-wa Chung, Sonja Ghidelli‐Disse, +27

Nature Communications

Repurposing clinically approved cephalosporins for tuberculosis therapy

Santiago Ramón‐García, Rubén González del Río, Angel Santos Villarejo, +7

Scientific Reports

Antitubercular drugs for an old target: GSK693 as a promising InhA direct inhibitor

María Martínez-Hoyos, Esther Pérez‐Herrán, Gülçin Gülten, +27

EBioMedicine