A Murine Model of falciparum-Malaria by In Vivo Selection of Competent Strains in Non-Myelodepleted Mice Engrafted with Human Erythrocytes

Íñigo Angulo‐Barturen, Marı́a Belén Jiménez-Dı́az, Teresa Mulet, +11

PLoS ONE

Discovery of a Potent and Specific <i>M. tuberculosis</i> Leucyl-tRNA Synthetase Inhibitor: (<i>S</i>)-3-(Aminomethyl)-4-chloro-7-(2-hydroxyethoxy)benzo[<i>c</i>][1,2]oxaborol-1(3<i>H</i>)-ol (GSK656)

Xianfeng Li, Vincent Hernandez, Fernando Rock, +18

Journal of Medicinal Chemistry

Tetrahydropyrazolo[1,5-a]Pyrimidine-3-Carboxamide and N-Benzyl-6′,7′-Dihydrospiro[Piperidine-4,4′-Thieno[3,2-c]Pyran] Analogues with Bactericidal Efficacy against Mycobacterium tuberculosis Targeting MmpL3

Modesto J. Remuiñán, Esther Pérez‐Herrán, Joaquín Rullás, +24

PLoS ONE

Tuberculosis PreventionLead SeriesAntimicrobial ChemotherapySpiro SeriesDrug Resistance +17

TRAF Family Proteins Link PKR with NF-κB Activation

Jesús Gil, María Ángel García, Paulino Gómez‐Puertas, +5

Molecular and Cellular Biology

Encoded Library Technology as a Source of Hits for the Discovery and Lead Optimization of a Potent and Selective Class of Bactericidal Direct Inhibitors of <i>Mycobacterium tuberculosis</i> InhA

Lourdes Encinas, Heather P. O’Keefe, Margarete Neu, +26

Journal of Medicinal Chemistry

Bioorganic ChemistryHit IdentificationPharmaceutical ChemistryDrug ResistanceMedicinal Chemistry +20

Discovery of Novel Oral Protein Synthesis Inhibitors of Mycobacterium tuberculosis That Target Leucyl-tRNA Synthetase

Andrés Palencia, Xianfeng Li, Wei Bu, +34

Antimicrobial Agents and Chemotherapy

Drug TargetMolecular BiologyAntimicrobial ChemotherapyProtein SynthesisDrug Resistance +16

The Hepatitis B Virus X Protein Induces HIV-1 Replication and Transcription in Synergy with T-cell Activation Signals

Marta Gómez-Gonzalo, Marta Carretero, Joaquín Rullás, +5

Journal of Biological Chemistry

Identification of KasA as the cellular target of an anti-tubercular scaffold

Katherine A. Abrahams, Chun-wa Chung, Sonja Ghidelli‐Disse, +27

Nature Communications

Improved BM212 MmpL3 Inhibitor Analogue Shows Efficacy in Acute Murine Model of Tuberculosis Infection

Giovanna Poce, Robert H. Bates, Salvatore Alfonso, +15

PLoS ONE

The catalytic activity of dsRNA-dependent protein kinase, PKR, is required for NF-κB activation

Jesús Gil, Joaquín Rullás, María Ángel García, +2

Oncogene

Transcriptional RegulationSignal TransductionSignaling PathwayMolecular PathwayCell Regulation +11