Vitamin E-TPGS Increases Absorption Flux of an HIV Protease Inhibitor by Enhancing Its Solubility and Permeability1

Lawrence X. Yu, Avis Bridgers, Joseph W. Polli, +5

Pharmaceutical Research

Design of Potent, Selective, and Orally Bioavailable Inhibitors of Cysteine Protease Cathepsin K

Francis X. Tavares, Virginia M. Boncek, David N. Deaton, +10

Journal of Medicinal Chemistry

Protein ChemistryRodent Osteoporosis ModelsMedicinal ChemistryPharmaceutical ChemistryBioorganic Chemistry +13

Dehydration, hydration behavior, and structural analysis of fenoprofen calcium**This work is presented in memory of one of the authors, Jia Xu.

Haijian Zhu, Jia Xu, Peter Varlashkin, +2

Journal of Pharmaceutical Sciences

Medicinal ChemistryBiochemistryHydration BehaviorNatural SciencesMedicine +5

P2–P3 conformationally constrained ketoamide-based inhibitors of cathepsin K

David G. Barrett, Virginia M. Boncek, John G. Catalano, +16

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyBiochemistryMedicineRational Drug DesignConformational Study +3

Enantiotropically-related polymorphs of {4-(4-chloro-3-fluorophenyl)-2-[4-(methyloxy)phenyl]-1,3-thiazol-5-yl} acetic acid: Crystal structures and multinuclear solid-state NMR

Frederick G. Vogt, Lee M. Katrincic, Stacey T. Long, +6

Journal of Pharmaceutical Sciences

EngineeringMultinuclear Solid-state NmrStructure ElucidationOrganic ChemistryEnantiotropically-related Polymorphs +5

Potent and selective P2–P3 ketoamide inhibitors of cathepsin K with good pharmacokinetic properties via favorable P1′, P1, and/or P3 substitutions

David G. Barrett, John G. Catalano, David N. Deaton, +8

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyPharmaceutical ChemistryGood Pharmacokinetic PropertiesBiochemistryMedicine +5

Design of small molecule ketoamide-based inhibitors of cathepsin K

John G. Catalano, David N. Deaton, Stacey T. Long, +5

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryPharmaceutical ChemistryNatural SciencesMedicineRational Drug Design +6

Novel, potent P2–P3 pyrrolidine derivatives of ketoamide-based cathepsin K inhibitors

David G. Barrett, John G. Catalano, David N. Deaton, +10

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyMedicinal ChemistryBiochemistryMedicineNatural Sciences +6

Excipient compatibility as assessed by isothermal microcalorimetry

Mark A. Phipps, Richard A. Winnike, Stacey T. Long, +1

Journal of Pharmacy and Pharmacology

Materials ScienceEngineeringDifferential Scanning CalorimetryThermodynamicsChemistry +4

Semicarbazone-based inhibitors of cathepsin K, are they prodrugs for aldehyde inhibitors?

Kim K. Adkison, David G. Barrett, David N. Deaton, +11

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryAldehyde InhibitorsBioorganic ChemistryPharmaceutical ScienceBiochemistry +11