Pooled In Vitro and In Vivo CRISPR-Cas9 Screening Identifies Tumor Suppressors in Human Colon Organoids

Birgitta E. Michels, Mohammed H. Mosa, Barbara Streibl, +10

Cell stem cell

Human Colon OrganoidsPathologyColorectal CancerGenome EngineeringGenome Editing +7

Autophagy Regulates IL-23 Secretion and Innate T Cell Responses through Effects on IL-1 Secretion

Celia Peral de Castro, Sarah A. Jones, Clíona Ní Cheallaigh, +6

The Journal of Immunology

Il-1 SecretionT-regulatory CellImmunologyImmune RegulationImmunologic Mechanism +15

Mapping of Wnt‐Frizzled interactions by multiplex CRISPR targeting of receptor gene families

Oksana Voloshanenko, Philipp Gmach, Jan Winter, +2

The FASEB Journal

Performance Evaluation of MHC Class-I Binding Prediction Tools Based on an Experimentally Validated MHC–Peptide Binding Data Set

Maria Bonsack, Stéphanie Hoppe, Jan Winter, +6

Cancer Immunology Research

CRISPR library designer (CLD): software for multispecies design of single guide RNA libraries

Florian Heigwer, Tianzuo Zhan, Marco Breinig, +4

Genome biology

GenomeCRISPR - a database for high-throughput CRISPR/Cas9 screens

Benedikt Rauscher, Florian Heigwer, Marco Breinig, +2

Nucleic Acids Research

EngineeringGeneticsDatabasesSingle Guide RnasGenomics +15

caRpools: an R package for exploratory data analysis and documentation of pooled CRISPR/Cas9 screens

Jan Winter, Marco Breinig, Florian Heigwer, +5

Bioinformatics

CRISPRAnalyzeR: Interactive analysis, annotation and documentation of pooled CRISPR screens

Jan Winter, Marc Schwering, Oliver Pelz, +4

EngineeringIn Vivo Gene TherapyBiomolecular ToolGeneticsMolecular Biology +22

Genome-scale CRISPR screening at high sensitivity with an empirically designed sgRNA library

Luisa Henkel, Benedikt Rauscher, Barbara Schmitt, +2

BMC Biology

ERAP1 overexpression in HPV-induced malignancies: A possible novel immune evasion mechanism

Alina Steinbach, Jan Winter, Miriam Reuschenbach, +7

OncoImmunology