Pooled In Vitro and In Vivo CRISPR-Cas9 Screening Identifies Tumor Suppressors in Human Colon Organoids

Birgitta E. Michels, Mohammed H. Mosa, Barbara Streibl, +10

Cell stem cell

Human Colon OrganoidsPathologyColorectal CancerGenome EngineeringGenome Editing +7

MEK inhibitors activate Wnt signalling and induce stem cell plasticity in colorectal cancer

Tianzuo Zhan, Giulia Ambrosi, Anna Maxi Wandmacher, +11

Nature Communications

Perioperative Atezolizumab Plus Fluorouracil, Leucovorin, Oxaliplatin, and Docetaxel for Resectable Esophagogastric Cancer: Interim Results From the Randomized, Multicenter, Phase II/III DANTE/IKF-s633 Trial

Sylvie Lorenzen, Thorsten Oliver Götze, Peter Thuss‐Patience, +23

Journal of Clinical Oncology

WGX50 mitigates doxorubicin-induced cardiotoxicity through inhibition of mitochondrial ROS and ferroptosis

Panpan Tai, Xinyu Chen, Guihua Jia, +26

Journal of Translational Medicine

Silybin and dehydrosilybin decrease glucose uptake by inhibiting GLUT proteins

Tianzuo Zhan, Margarete Digel, Eva‐Maria Küch, +2

Journal of Cellular Biochemistry

Metabolic SyndromeInsulin SignalingBiochemistryMedicineLiver Physiology +13

CRISPR library designer (CLD): software for multispecies design of single guide RNA libraries

Florian Heigwer, Tianzuo Zhan, Marco Breinig, +4

Genome biology

Overexpressed FATP1, ACSVL4/FATP4 and ACSL1 Increase the Cellular Fatty Acid Uptake of 3T3-L1 Adipocytes but Are Localized on Intracellular Membranes

Tianzuo Zhan, Margarete Poppelreuther, Robert Ehehalt, +1

PLoS ONE

3T3-l1 AdipocytesCellular PhysiologyMetabolic SyndromeFatty AcidsCellular Uptake +19

The drug-induced phenotypic landscape of colorectal cancer organoids

Johannes Betge, Niklas Rindtorff, Jan Sauer, +22

Nature Communications

caRpools: an R package for exploratory data analysis and documentation of pooled CRISPR/Cas9 screens

Jan Winter, Marco Breinig, Florian Heigwer, +5

Bioinformatics

CRISPRAnalyzeR: Interactive analysis, annotation and documentation of pooled CRISPR screens

Jan Winter, Marc Schwering, Oliver Pelz, +4

EngineeringIn Vivo Gene TherapyBiomolecular ToolGeneticsMolecular Biology +22