Jennifer Lafontaine

A Pre-mRNA Degradation Pathway that Selectively Targets Intron-Containing Genes Requires the Nuclear Poly(A)-Binding Protein

Caroline Lemieux, Samuel Marguerat, Jennifer Lafontaine et al. · Molecular Cell · 2011 · 100 citations · Full text

Life Sciences, Genetics, Molecular Biology +16

Discovery of <i>N</i>-((3<i>R</i>,4<i>R</i>)-4-Fluoro-1-(6-((3-methoxy-1-methyl-1<i>H</i>-pyrazol-4-yl)amino)-9-methyl-9<i>H</i>-purin-2-yl)pyrrolidine-3-yl)acrylamide (PF-06747775) through Structure-Based Drug Design: A High Affinity Irreversible Inhibitor Targeting Oncogenic EGFR Mutants with Selectivity over Wild-Type EGFR

Simon Planken, Douglas C. Behenna, Sajiv K. Nair et al. · Journal of Medicinal Chemistry · 2017 · 90 citations · Full text

Medicine, Oncology, Pharmacology +12

Enantioselective Total Synthesis of the Antitumor Macrolide Rhizoxin D

Jennifer Lafontaine, David P. Provencal, Cristina Gardelli et al. · The Journal of Organic Chemistry · 2003 · 89 citations

Pharmacy, Chemistry, Medicinal Chemistry +9

Effect of PF-04217329 a prodrug of a selective prostaglandin EP2 agonist on intraocular pressure in preclinical models of glaucoma

Ganesh Prasanna, Samantha Carreiro, Scott Anderson et al. · Experimental Eye Research · 2011 · 66 citations

Medicine, Ophthalmology, Pharmacology +11

Synthesis and Diastereoselective Complexation of Enantiopure Sulfinyl Dienes:  The Preparation of Sulfinyl Iron(0) Dienes

Robert S. Paley, Alfonso de Dios, Lara A. Estroff et al. · The Journal of Organic Chemistry · 1997 · 66 citations

Natural Sciences, Chemistry, Catalysis +16