Discovery of Raltegravir, a Potent, Selective Orally Bioavailable HIV-Integrase Inhibitor for the Treatment of HIV-AIDS Infection

Vincenzo Summa, Alessia Petrocchi, Fabio Bonelli, +20

Journal of Medicinal Chemistry

Antiviral DrugMedicinal ChemistryAntiviral Drug DevelopmentResistance Mutation (Virology)Biochemistry +14

4,5-Dihydroxypyrimidine Carboxamides and <i>N</i>-Alkyl-5-hydroxypyrimidinone Carboxamides Are Potent, Selective HIV Integrase Inhibitors with Good Pharmacokinetic Profiles in Preclinical Species

Vincenzo Summa, Alessia Petrocchi, Victor G. Matassa, +7

Journal of Medicinal Chemistry

Bioorganic ChemistryPharmacotherapyAntiviral DrugMedicinal Chemistry4,5-Dihydroxypyrimidine Carboxamides +15

Enantioselective Total Synthesis of the Antitumor Macrolide Rhizoxin D

Jennifer Lafontaine, David P. Provencal, Cristina Gardelli, +1

The Journal of Organic Chemistry

Dihydroxypyrimidine-4-carboxamides as Novel Potent and Selective HIV Integrase Inhibitors

Paola Pace, Maria Emilia Di Francesco, Cristina Gardelli, +15

Journal of Medicinal Chemistry

Combinatorial ChemistryMedicinal ChemistryBioorganic ChemistryInteresting CompoundsBiochemistry +13

Discovery and Synthesis of HIV Integrase Inhibitors:  Development of Potent and Orally Bioavailable N-Methyl Pyrimidones

Cristina Gardelli, Emanuela Nizi, Ester Muraglia, +23

Journal of Medicinal Chemistry

Medicinal ChemistryInteresting CompoundsBiochemistryMedicineDrug Discovery +13

Phosphoramidate Prodrugs of 2′-<i>C</i>-Methylcytidine for Therapy of Hepatitis C Virus Infection

Cristina Gardelli, Barbara Attenni, Monica Donghi, +15

Journal of Medicinal Chemistry

Design and Synthesis of Bicyclic Pyrimidinones as Potent and Orally Bioavailable HIV-1 Integrase Inhibitors

Ester Muraglia, Olaf Kinzel, Cristina Gardelli, +15

Journal of Medicinal Chemistry

The Design and Enzyme-Bound Crystal Structure of Indoline Based Peptidomimetic Inhibitors of Hepatitis C Virus NS3 Protease

Jesus M. Ontoria, Stefania Di Marco, Immacolata Conte, +8

Journal of Medicinal Chemistry

Crystal StructureMedicinal ChemistryNs3 ProteaseBioorganic ChemistryBiochemistry +13

Discovery of Highly Isoform Selective Orally Bioavailable Phosphoinositide 3-Kinase (PI3K)-γ Inhibitors

Nils Pemberton, Mickael Mogemark, Susanne Arlbrandt, +18

Journal of Medicinal Chemistry

Pharmaceutical ScienceLung InflammationImmunologyPharmacotherapySelective Pi3kγ Inhibitor +16

Synthesis and evaluation of novel phosphoramidate prodrugs of 2′-methyl cytidine as inhibitors of hepatitis c virus NS5B polymerase

Monica Donghi, Barbara Attenni, Cristina Gardelli, +8

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryNovel Phosphoramidate ProdrugsBiochemistryHepatitis CMedicine +9