Novel Foxo1-dependent transcriptional programs control Treg cell function

Weiming Ouyang, Will Liao, Chong Luo, +13

Nature

Transcriptional RegulationSignal TransductionTreg Cell FunctionGene RegulationRegulatory T Cells +6

Antibody-based targeting of FGFR3 in bladder carcinoma and t(4;14)-positive multiple myeloma in mice

Jing Qing, Xiangnan Du, Yongmei Chen, +16

Journal of Clinical Investigation

Bladder CarcinomaFgf Receptor 3Genitourinary CancerMedicineImmunology +13

Antibody-Drug Conjugates for the Treatment of Non–Hodgkin's Lymphoma: Target and Linker-Drug Selection

Andrew G. Polson, Jill Calemine-Fenaux, Pamela Chan, +26

Cancer Research

ImmunologyChemical LinkersImmunotherapeuticsImmunotherapyTumor Biology +15

A strategy for risk mitigation of antibodies with fast clearance

Isidro Hötzel, Frank‐Peter Theil, L. Bernstein, +10

mAbs

Trem2 Deletion Reduces Late-Stage Amyloid Plaque Accumulation, Elevates the Aβ42:Aβ40 Ratio, and Exacerbates Axonal Dystrophy and Dendritic Spine Loss in the PS2APP Alzheimer's Mouse Model

William J. Meilandt, Hai Ngu, Alvin Gogineni, +16

Journal of Neuroscience

Synaptic SignalingPs2app AlzheimerSocial SciencesNeuroinflammationAlzheimer's Disease +19

Antibodies against the gH/gL/UL128/UL130/UL131 Complex Comprise the Majority of the Anti-Cytomegalovirus (Anti-CMV) Neutralizing Antibody Response in CMV Hyperimmune Globulin

Ashley E. Fouts, Pamela Chan, Jean-Philippe Stéphan, +2

Journal of Virology

HistocompatibilityViral PathogenesisImmunologyAntigen ProcessingImmunotherapy +18

T Cell-Derived Protein S Engages TAM Receptor Signaling in Dendritic Cells to Control the Magnitude of the Immune Response

Eugenio Antonio Carrera Silva, Pamela Chan, Leonel Joannas, +13

Immunity

Autoimmune DiseaseAllergyT-regulatory CellImmunologyAntigen Processing +8

The Wnt Antagonist Dickkopf-1 Promotes Pathological Type 2 Cell-Mediated Inflammation

Wook‐Jin Chae, Allison Ehrlich, Pamela Chan, +16

Immunity

InflammationCytokineAnti-inflammatoryInflammatory DiseaseAutoimmune Disease +9

The Immunoglobulin Superfamily Receptome Defines Cancer-Relevant Networks Associated with Clinical Outcome

Erik Verschueren, Bushra Husain, Kobe Yuen, +16

Cell

Clinical OutcomeCancer ImmunosurveillanceImmunotherapyMedicineImmunology +8

The TAM family receptor tyrosine kinase TYRO3 is a negative regulator of type 2 immunity

Pamela Chan, Eugenio Antonio Carrera Silva, Dimitri de Kouchkovsky, +16

Science